Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 394848..395370 Replicon chromosome
Accession NZ_CP097338
Organism Mannheimia haemolytica strain P1148

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZX63
Locus tag M3708_RS02070 Protein ID WP_006250322.1
Coordinates 395101..395370 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A248ZY54
Locus tag M3708_RS02065 Protein ID WP_006250323.1
Coordinates 394848..395114 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3708_RS02050 (M3708_02050) 391709..393094 - 1386 WP_006253648.1 GTPase HflX -
M3708_RS02055 (M3708_02055) 393114..393386 - 273 WP_006250326.1 RNA chaperone Hfq -
M3708_RS02060 (M3708_02060) 393455..394408 - 954 WP_006250325.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
M3708_RS02065 (M3708_02065) 394848..395114 + 267 WP_006250323.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3708_RS02070 (M3708_02070) 395101..395370 + 270 WP_006250322.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
M3708_RS02075 (M3708_02075) 395389..397272 - 1884 WP_006250321.1 DNA mismatch repair endonuclease MutL -
M3708_RS02080 (M3708_02080) 397556..398794 + 1239 WP_006250320.1 glutamate-5-semialdehyde dehydrogenase -
M3708_RS02085 (M3708_02085) 398796..399641 + 846 WP_006250319.1 virulence factor BrkB family protein -
M3708_RS02090 (M3708_02090) 399616..400050 + 435 WP_006250318.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10447.99 Da        Isoelectric Point: 6.4732

>T245215 WP_006250322.1 NZ_CP097338:395101-395370 [Mannheimia haemolytica]
MREIEYSNAFKRDYKKCAVESLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKVEDDKLELLR
IGSHSHLFG

Download         Length: 270 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9738.10 Da        Isoelectric Point: 4.7954

>AT245215 WP_006250323.1 NZ_CP097338:394848-395114 [Mannheimia haemolytica]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNFETAEVLRAVKNGEEKLHSANSIADL
MEQLNARD

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZX63

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZY54

References