Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 77202..77917 Replicon chromosome
Accession NZ_CP097338
Organism Mannheimia haemolytica strain P1148

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M3708_RS00385 Protein ID WP_006250491.1
Coordinates 77202..77630 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A248ZW87
Locus tag M3708_RS00390 Protein ID WP_006248272.1
Coordinates 77630..77917 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3708_RS00370 (M3708_00370) 72456..74108 + 1653 WP_006248275.1 phospho-sugar mutase -
M3708_RS00375 (M3708_00375) 74161..75095 + 935 Protein_75 nucleoside hydrolase -
M3708_RS00380 (M3708_00380) 75117..77198 - 2082 WP_006248274.1 ATP-dependent DNA helicase RecG -
M3708_RS00385 (M3708_00385) 77202..77630 - 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
M3708_RS00390 (M3708_00390) 77630..77917 - 288 WP_006248272.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M3708_RS00395 (M3708_00395) 78081..79964 + 1884 WP_006248270.1 molecular chaperone HtpG -
M3708_RS13530 80053..80178 + 126 WP_006248269.1 hypothetical protein -
M3708_RS00400 (M3708_00400) 80342..82057 + 1716 WP_006248268.1 proline--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T245213 WP_006250491.1 NZ_CP097338:c77630-77202 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11085.39 Da        Isoelectric Point: 4.3648

>AT245213 WP_006248272.1 NZ_CP097338:c77917-77630 [Mannheimia haemolytica]
MAITITSREFNQNASKVLKMAEKEPVFITKWGKIVNVVSSYMDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVE
IRKSNKPRPVDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZW87

References