Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 2471964..2472679 Replicon chromosome
Accession NZ_CP097337
Organism Mannheimia haemolytica strain NCTC 9712

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M3706_RS12445 Protein ID WP_006250491.1
Coordinates 2471964..2472392 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A248ZW87
Locus tag M3706_RS12450 Protein ID WP_006248272.1
Coordinates 2472392..2472679 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3706_RS12430 (M3706_12430) 2467220..2468872 + 1653 WP_006250488.1 phospho-sugar mutase -
M3706_RS12435 (M3706_12435) 2468925..2469857 + 933 WP_006250489.1 nucleoside hydrolase -
M3706_RS12440 (M3706_12440) 2469879..2471960 - 2082 WP_006250490.1 ATP-dependent DNA helicase RecG -
M3706_RS12445 (M3706_12445) 2471964..2472392 - 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
M3706_RS12450 (M3706_12450) 2472392..2472679 - 288 WP_006248272.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M3706_RS12455 (M3706_12455) 2472843..2474726 + 1884 WP_006250492.1 molecular chaperone HtpG -
M3706_RS12460 (M3706_12460) 2474779..2474961 + 183 WP_006250493.1 hypothetical protein -
M3706_RS12465 (M3706_12465) 2475125..2476840 + 1716 WP_006248268.1 proline--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T245212 WP_006250491.1 NZ_CP097337:c2472392-2471964 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11085.39 Da        Isoelectric Point: 4.3648

>AT245212 WP_006248272.1 NZ_CP097337:c2472679-2472392 [Mannheimia haemolytica]
MAITITSREFNQNASKVLKMAEKEPVFITKWGKIVNVVSSYMDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVE
IRKSNKPRPVDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZW87

References