Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1961285..1961935 Replicon chromosome
Accession NZ_CP097337
Organism Mannheimia haemolytica strain NCTC 9712

Toxin (Protein)


Gene name vapC Uniprot ID A0A378NBZ4
Locus tag M3706_RS09900 Protein ID WP_020831127.1
Coordinates 1961285..1961674 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D2Q6P1
Locus tag M3706_RS09905 Protein ID WP_006251766.1
Coordinates 1961675..1961935 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3706_RS09860 (M3706_09860) 1956846..1957655 - 810 WP_006250123.1 metal ABC transporter permease -
M3706_RS09865 (M3706_09865) 1957648..1958508 - 861 WP_006250124.1 metal ABC transporter permease -
M3706_RS09870 (M3706_09870) 1958582..1959367 - 786 WP_006251768.1 hypothetical protein -
M3706_RS09895 (M3706_09895) 1960027..1961265 - 1239 WP_006251767.1 peptidase T -
M3706_RS09900 (M3706_09900) 1961285..1961674 - 390 WP_020831127.1 type II toxin-antitoxin system VapC family toxin Toxin
M3706_RS09905 (M3706_09905) 1961675..1961935 - 261 WP_006251766.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M3706_RS09910 (M3706_09910) 1962051..1962263 - 213 WP_006251765.1 BrnA antitoxin family protein -
M3706_RS09915 (M3706_09915) 1962264..1962551 - 288 WP_006251764.1 BrnT family toxin -
M3706_RS09920 (M3706_09920) 1962714..1966247 - 3534 WP_006251763.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14575.87 Da        Isoelectric Point: 7.7391

>T245211 WP_020831127.1 NZ_CP097337:c1961674-1961285 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLGYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.50 Da        Isoelectric Point: 4.6909

>AT245211 WP_006251766.1 NZ_CP097337:c1961935-1961675 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKQENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378NBZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1D2Q6P1

References