Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 2620648..2621363 Replicon chromosome
Accession NZ_CP097336
Organism Mannheimia haemolytica strain NCTC 10636

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M3705_RS13290 Protein ID WP_006250491.1
Coordinates 2620648..2621076 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A248ZW87
Locus tag M3705_RS13295 Protein ID WP_006248272.1
Coordinates 2621076..2621363 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3705_RS13275 (M3705_13275) 2615904..2617556 + 1653 WP_249763762.1 phospho-sugar mutase -
M3705_RS13280 (M3705_13280) 2617609..2618541 + 933 WP_015484792.1 nucleoside hydrolase -
M3705_RS13285 (M3705_13285) 2618563..2620644 - 2082 WP_040080489.1 ATP-dependent DNA helicase RecG -
M3705_RS13290 (M3705_13290) 2620648..2621076 - 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
M3705_RS13295 (M3705_13295) 2621076..2621363 - 288 WP_006248272.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M3705_RS13300 (M3705_13300) 2621527..2623410 + 1884 WP_040080490.1 molecular chaperone HtpG -
M3705_RS13305 (M3705_13305) 2623499..2623645 + 147 WP_230269068.1 hypothetical protein -
M3705_RS13310 (M3705_13310) 2623790..2624830 + 1041 WP_249763655.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2615225..2615851 626
- flank IS/Tn - - 2623790..2624830 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T245204 WP_006250491.1 NZ_CP097336:c2621076-2620648 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11085.39 Da        Isoelectric Point: 4.3648

>AT245204 WP_006248272.1 NZ_CP097336:c2621363-2621076 [Mannheimia haemolytica]
MAITITSREFNQNASKVLKMAEKEPVFITKWGKIVNVVSSYMDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVE
IRKSNKPRPVDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZW87

References