Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2098208..2098858 Replicon chromosome
Accession NZ_CP097336
Organism Mannheimia haemolytica strain NCTC 10636

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag M3705_RS10740 Protein ID WP_006249411.1
Coordinates 2098208..2098597 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A547EDM1
Locus tag M3705_RS10745 Protein ID WP_006249412.1
Coordinates 2098598..2098858 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3705_RS10695 (M3705_10695) 2093687..2094496 - 810 WP_006250123.1 metal ABC transporter permease -
M3705_RS10700 (M3705_10700) 2094489..2095349 - 861 WP_006250124.1 metal ABC transporter permease -
M3705_RS10705 (M3705_10705) 2095423..2096208 - 786 WP_006251768.1 hypothetical protein -
M3705_RS10735 (M3705_10735) 2096950..2098188 - 1239 WP_006253630.1 peptidase T -
M3705_RS10740 (M3705_10740) 2098208..2098597 - 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
M3705_RS10745 (M3705_10745) 2098598..2098858 - 261 WP_006249412.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M3705_RS10750 (M3705_10750) 2098974..2099186 - 213 WP_006251765.1 BrnA antitoxin family protein -
M3705_RS10755 (M3705_10755) 2099187..2099474 - 288 WP_006251764.1 BrnT family toxin -
M3705_RS10760 (M3705_10760) 2099637..2103170 - 3534 WP_006253629.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T245203 WP_006249411.1 NZ_CP097336:c2098597-2098208 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.54 Da        Isoelectric Point: 4.8951

>AT245203 WP_006249412.1 NZ_CP097336:c2098858-2098598 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKKENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A547EDM1

References