Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1797417..1797939 Replicon chromosome
Accession NZ_CP097336
Organism Mannheimia haemolytica strain NCTC 10636

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag M3705_RS09190 Protein ID WP_006249269.1
Coordinates 1797643..1797939 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag M3705_RS09185 Protein ID WP_006249270.1
Coordinates 1797417..1797659 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3705_RS09160 (M3705_09160) 1793255..1794344 - 1090 Protein_1777 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
M3705_RS09165 (M3705_09165) 1794518..1795159 - 642 WP_249763691.1 orotate phosphoribosyltransferase -
M3705_RS09170 (M3705_09170) 1795282..1796124 - 843 WP_006249273.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
M3705_RS09175 (M3705_09175) 1796184..1796759 + 576 WP_006249272.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
M3705_RS09180 (M3705_09180) 1796737..1797405 - 669 WP_006249271.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
M3705_RS09185 (M3705_09185) 1797417..1797659 - 243 WP_006249270.1 CopG family antitoxin Antitoxin
M3705_RS09190 (M3705_09190) 1797643..1797939 - 297 WP_006249269.1 BrnT family toxin Toxin
M3705_RS09195 (M3705_09195) 1798066..1800978 - 2913 WP_006249267.1 RNA polymerase-associated protein RapA -
M3705_RS09200 (M3705_09200) 1801139..1801438 - 300 WP_006249265.1 hypothetical protein -
M3705_RS09205 (M3705_09205) 1801559..1802884 - 1326 WP_020831251.1 anti-phage deoxyguanosine triphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T245202 WP_006249269.1 NZ_CP097336:c1797939-1797643 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT245202 WP_006249270.1 NZ_CP097336:c1797659-1797417 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A107

Antitoxin

Source ID Structure
AlphaFold DB A0A249A190

References