Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 823898..824495 Replicon chromosome
Accession NZ_CP097336
Organism Mannheimia haemolytica strain NCTC 10636

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M3705_RS04285 Protein ID WP_044427636.1
Coordinates 824220..824495 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A547EKP0
Locus tag M3705_RS04280 Protein ID WP_006249777.1
Coordinates 823898..824227 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3705_RS04255 (M3705_04255) 819339..820028 + 690 WP_249763870.1 GTP cyclohydrolase I FolE -
M3705_RS04260 (M3705_04260) 820101..820886 + 786 WP_031200754.1 tRNA pseudouridine(38-40) synthase TruA -
M3705_RS04265 (M3705_04265) 820939..823131 - 2193 WP_249763871.1 copper-translocating P-type ATPase -
M3705_RS04270 (M3705_04270) 823184..823384 - 201 WP_249762742.1 cation transporter -
M3705_RS04275 (M3705_04275) 823473..823859 + 387 WP_006249778.1 Cu(I)-responsive transcriptional regulator -
M3705_RS04280 (M3705_04280) 823898..824227 - 330 WP_006249777.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M3705_RS04285 (M3705_04285) 824220..824495 - 276 WP_044427636.1 type II toxin-antitoxin system HicA family toxin Toxin
M3705_RS04290 (M3705_04290) 824703..826610 + 1908 WP_044427633.1 DNA topoisomerase IV subunit B -
M3705_RS04295 (M3705_04295) 826684..827289 - 606 WP_006249773.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
M3705_RS04300 (M3705_04300) 827359..827715 + 357 WP_006249772.1 dihydroneopterin aldolase -
M3705_RS04305 (M3705_04305) 827712..828613 + 902 Protein_818 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(28-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10384.08 Da        Isoelectric Point: 10.2600

>T245198 WP_044427636.1 NZ_CP097336:c824495-824220 [Mannheimia haemolytica]
MVVKILKRKSQKTLQQIYTQPISANIKWTNIEALFLELGAEIEEREGSRIAVVLFQQVRVFHRPHPNPDTDKGAVASIKK
WLSENGVIPYA

Download         Length: 276 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12312.06 Da        Isoelectric Point: 4.7022

>AT245198 WP_006249777.1 NZ_CP097336:c824227-823898 [Mannheimia haemolytica]
MRNIMDINGYKAVIAYDPETELFRGEFIGLNGGADFYADNVIQLKKEGELSLNIFLELCREKGIEPFKQYSGKFNVRLSP
ELHKAAVIAATAENLSLNEWINQTLEKSV

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A547EKP0

References