Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 788974..789569 Replicon chromosome
Accession NZ_CP097335
Organism Mannheimia haemolytica strain NCTC 10208

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M3704_RS03830 Protein ID WP_230311452.1
Coordinates 789372..789569 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A547EKP0
Locus tag M3704_RS03825 Protein ID WP_006249777.1
Coordinates 788974..789303 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3704_RS03800 (M3704_03800) 784429..785118 + 690 WP_126301809.1 GTP cyclohydrolase I FolE -
M3704_RS03805 (M3704_03805) 785179..785964 + 786 WP_126301810.1 tRNA pseudouridine(38-40) synthase TruA -
M3704_RS03810 (M3704_03810) 786016..788208 - 2193 WP_154704537.1 copper-translocating P-type ATPase -
M3704_RS03815 (M3704_03815) 788260..788460 - 201 WP_154704793.1 heavy metal-associated domain-containing protein -
M3704_RS03820 (M3704_03820) 788549..788935 + 387 WP_154704536.1 Cu(I)-responsive transcriptional regulator -
M3704_RS03825 (M3704_03825) 788974..789303 - 330 WP_006249777.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M3704_RS03830 (M3704_03830) 789372..789569 - 198 WP_230311452.1 type II toxin-antitoxin system HicA family toxin Toxin
M3704_RS03835 (M3704_03835) 789777..791684 + 1908 WP_154704535.1 DNA topoisomerase IV subunit B -
M3704_RS03840 (M3704_03840) 791758..792363 - 606 WP_006249773.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
M3704_RS03845 (M3704_03845) 792433..792789 + 357 WP_126301814.1 dihydroneopterin aldolase -
M3704_RS03850 (M3704_03850) 792786..793688 + 903 WP_154704534.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7590.95 Da        Isoelectric Point: 10.6733

>T245192 WP_230311452.1 NZ_CP097335:c789569-789372 [Mannheimia haemolytica]
MVVKILKRKSQKTLQQIYTQPISANIKWTNIEALFLELGAEIEEREGSRIAVVLFQQVRVFHRPP

Download         Length: 198 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12312.06 Da        Isoelectric Point: 4.7022

>AT245192 WP_006249777.1 NZ_CP097335:c789303-788974 [Mannheimia haemolytica]
MRNIMDINGYKAVIAYDPETELFRGEFIGLNGGADFYADNVIQLKKEGELSLNIFLELCREKGIEPFKQYSGKFNVRLSP
ELHKAAVIAATAENLSLNEWINQTLEKSV

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A547EKP0

References