Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 290715..291237 Replicon chromosome
Accession NZ_CP097335
Organism Mannheimia haemolytica strain NCTC 10208

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZX63
Locus tag M3704_RS01405 Protein ID WP_006250322.1
Coordinates 290968..291237 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A248ZY54
Locus tag M3704_RS01400 Protein ID WP_006250323.1
Coordinates 290715..290981 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3704_RS01385 (M3704_01385) 287878..289263 - 1386 WP_154703466.1 GTPase HflX -
M3704_RS01390 (M3704_01390) 289283..289555 - 273 WP_126301178.1 RNA chaperone Hfq -
M3704_RS01395 (M3704_01395) 289624..290577 - 954 WP_154703465.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
M3704_RS01400 (M3704_01400) 290715..290981 + 267 WP_006250323.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3704_RS01405 (M3704_01405) 290968..291237 + 270 WP_006250322.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
M3704_RS01410 (M3704_01410) 291256..293169 - 1914 WP_154703464.1 DNA mismatch repair endonuclease MutL -
M3704_RS01415 (M3704_01415) 293475..294713 + 1239 WP_154703463.1 glutamate-5-semialdehyde dehydrogenase -
M3704_RS01420 (M3704_01420) 294715..295560 + 846 WP_006251985.1 virulence factor BrkB family protein -
M3704_RS01425 (M3704_01425) 295535..295969 + 435 WP_126301174.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10447.99 Da        Isoelectric Point: 6.4732

>T245191 WP_006250322.1 NZ_CP097335:290968-291237 [Mannheimia haemolytica]
MREIEYSNAFKRDYKKCAVESLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKVEDDKLELLR
IGSHSHLFG

Download         Length: 270 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9738.10 Da        Isoelectric Point: 4.7954

>AT245191 WP_006250323.1 NZ_CP097335:290715-290981 [Mannheimia haemolytica]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNFETAEVLRAVKNGEEKLHSANSIADL
MEQLNARD

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZX63

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZY54

References