Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 36040..36737 Replicon chromosome
Accession NZ_CP097335
Organism Mannheimia haemolytica strain NCTC 10208

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M3704_RS00165 Protein ID WP_154703611.1
Coordinates 36040..36462 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M3704_RS00170 Protein ID WP_154703610.1
Coordinates 36462..36737 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3704_RS00150 (M3704_00150) 31296..32948 + 1653 WP_154703614.1 phospho-sugar mutase -
M3704_RS00155 (M3704_00155) 33001..33933 + 933 WP_154703613.1 nucleoside hydrolase -
M3704_RS00160 (M3704_00160) 33955..36036 - 2082 WP_154703612.1 ATP-dependent DNA helicase RecG -
M3704_RS00165 (M3704_00165) 36040..36462 - 423 WP_154703611.1 type II toxin-antitoxin system VapC family toxin Toxin
M3704_RS00170 (M3704_00170) 36462..36737 - 276 WP_154703610.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M3704_RS00175 (M3704_00175) 36901..38784 + 1884 WP_154703609.1 molecular chaperone HtpG -
M3704_RS00180 (M3704_00180) 38920..40635 + 1716 WP_154703608.1 proline--tRNA ligase -
M3704_RS00185 (M3704_00185) 40745..40801 + 57 Protein_36 PT domain-containing protein -
M3704_RS00190 (M3704_00190) 40797..40856 + 60 Protein_37 PT domain-containing protein -
M3704_RS00195 (M3704_00195) 40852..40903 + 52 Protein_38 PT domain-containing protein -
M3704_RS00200 (M3704_00200) 40951..41733 + 783 WP_230311465.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16213.77 Da        Isoelectric Point: 7.6667

>T245190 WP_154703611.1 NZ_CP097335:c36462-36040 [Mannheimia haemolytica]
MYLLDTNIVSELRKASKGRADPNVMRWFSKVELQDCYLCSTVISEIRVGILAKKKRDVEQYYILNDWFENQLLTQFSNRI
LPLDLTAALLCAEFHIPDRSPINDAYIAAIAKANHLTLVTRNTKDFIRCDLRLFNPFETA

Download         Length: 423 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10521.99 Da        Isoelectric Point: 4.6582

>AT245190 WP_154703610.1 NZ_CP097335:c36737-36462 [Mannheimia haemolytica]
MAITITSREFNQNASKVLKMAEKEPVFITKWGKVVNVVSSYMDYQQKAKPQTLADVFASPVVEEDDVDMEDFEQILRDIR
KNSKCRTVEFD

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References