Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2185370..2186020 Replicon chromosome
Accession NZ_CP097334
Organism Mannheimia haemolytica strain 183

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag M3707_RS11255 Protein ID WP_006249411.1
Coordinates 2185370..2185759 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A547EDM1
Locus tag M3707_RS11260 Protein ID WP_006249412.1
Coordinates 2185760..2186020 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3707_RS11200 (M3707_11200) 2180641..2181450 - 810 WP_006250123.1 metal ABC transporter permease -
M3707_RS11205 (M3707_11205) 2181443..2182303 - 861 WP_006250124.1 metal ABC transporter permease -
M3707_RS11210 (M3707_11210) 2182377..2183162 - 786 WP_006251768.1 hypothetical protein -
M3707_RS11250 (M3707_11250) 2184112..2185350 - 1239 WP_006253630.1 peptidase T -
M3707_RS11255 (M3707_11255) 2185370..2185759 - 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
M3707_RS11260 (M3707_11260) 2185760..2186020 - 261 WP_006249412.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M3707_RS11265 (M3707_11265) 2186136..2186348 - 213 WP_006251765.1 BrnA antitoxin family protein -
M3707_RS11270 (M3707_11270) 2186349..2186636 - 288 WP_006251764.1 BrnT family toxin -
M3707_RS11275 (M3707_11275) 2186799..2190332 - 3534 WP_006253629.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T245189 WP_006249411.1 NZ_CP097334:c2185759-2185370 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.54 Da        Isoelectric Point: 4.8951

>AT245189 WP_006249412.1 NZ_CP097334:c2186020-2185760 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKKENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A547EDM1

References