Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1893761..1894283 Replicon chromosome
Accession NZ_CP097334
Organism Mannheimia haemolytica strain 183

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag M3707_RS09755 Protein ID WP_006249269.1
Coordinates 1893987..1894283 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag M3707_RS09750 Protein ID WP_006249270.1
Coordinates 1893761..1894003 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3707_RS09725 (M3707_09725) 1889599..1890688 - 1090 Protein_1890 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
M3707_RS09730 (M3707_09730) 1890862..1891503 - 642 WP_006249274.1 orotate phosphoribosyltransferase -
M3707_RS09735 (M3707_09735) 1891626..1892468 - 843 WP_006249273.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
M3707_RS09740 (M3707_09740) 1892528..1893103 + 576 WP_006249272.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
M3707_RS09745 (M3707_09745) 1893081..1893749 - 669 WP_006249271.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
M3707_RS09750 (M3707_09750) 1893761..1894003 - 243 WP_006249270.1 CopG family antitoxin Antitoxin
M3707_RS09755 (M3707_09755) 1893987..1894283 - 297 WP_006249269.1 BrnT family toxin Toxin
M3707_RS09760 (M3707_09760) 1894410..1897322 - 2913 WP_006249267.1 RNA polymerase-associated protein RapA -
M3707_RS09765 (M3707_09765) 1897483..1897782 - 300 WP_006249265.1 hypothetical protein -
M3707_RS09770 (M3707_09770) 1897903..1899228 - 1326 WP_006249264.1 anti-phage deoxyguanosine triphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T245188 WP_006249269.1 NZ_CP097334:c1894283-1893987 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT245188 WP_006249270.1 NZ_CP097334:c1894003-1893761 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A107

Antitoxin

Source ID Structure
AlphaFold DB A0A249A190

References