Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 860414..861010 Replicon chromosome
Accession NZ_CP097334
Organism Mannheimia haemolytica strain 183

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M3707_RS04350 Protein ID WP_006249776.1
Coordinates 860786..861010 (-) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A547EKP0
Locus tag M3707_RS04345 Protein ID WP_006249777.1
Coordinates 860414..860743 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3707_RS04320 (M3707_04320) 855863..856552 + 690 WP_006253589.1 GTP cyclohydrolase I FolE -
M3707_RS04325 (M3707_04325) 856617..857402 + 786 WP_006249781.1 tRNA pseudouridine(38-40) synthase TruA -
M3707_RS04330 (M3707_04330) 857455..859647 - 2193 WP_006249780.1 copper-translocating P-type ATPase -
M3707_RS04335 (M3707_04335) 859700..859900 - 201 WP_006249779.1 heavy metal-associated domain-containing protein -
M3707_RS04340 (M3707_04340) 859989..860375 + 387 WP_006249778.1 Cu(I)-responsive transcriptional regulator -
M3707_RS04345 (M3707_04345) 860414..860743 - 330 WP_006249777.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M3707_RS04350 (M3707_04350) 860786..861010 - 225 WP_006249776.1 type II toxin-antitoxin system HicA family toxin Toxin
M3707_RS04355 (M3707_04355) 861218..863125 + 1908 WP_006249774.1 DNA topoisomerase IV subunit B -
M3707_RS04360 (M3707_04360) 863199..863804 - 606 WP_006249773.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
M3707_RS04365 (M3707_04365) 863874..864230 + 357 WP_006249772.1 dihydroneopterin aldolase -
M3707_RS04370 (M3707_04370) 864227..865129 + 903 WP_006249771.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(28-73)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 10.5597

>T245184 WP_006249776.1 NZ_CP097334:c861010-860786 [Mannheimia haemolytica]
MVVKILKRKSQKTLQQIYTQPISANIKWTNIEALFLELGAEIEEREGSRIAVVLFQQVRVFHRPHPNPDTDKGR

Download         Length: 225 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12312.06 Da        Isoelectric Point: 4.7022

>AT245184 WP_006249777.1 NZ_CP097334:c860743-860414 [Mannheimia haemolytica]
MRNIMDINGYKAVIAYDPETELFRGEFIGLNGGADFYADNVIQLKKEGELSLNIFLELCREKGIEPFKQYSGKFNVRLSP
ELHKAAVIAATAENLSLNEWINQTLEKSV

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A547EKP0

References