Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 350283..350805 Replicon chromosome
Accession NZ_CP097334
Organism Mannheimia haemolytica strain 183

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZX63
Locus tag M3707_RS01795 Protein ID WP_006250322.1
Coordinates 350536..350805 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A248ZY54
Locus tag M3707_RS01790 Protein ID WP_006250323.1
Coordinates 350283..350549 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3707_RS01775 (M3707_01775) 347144..348529 - 1386 WP_006253648.1 GTPase HflX -
M3707_RS01780 (M3707_01780) 348549..348821 - 273 WP_006250326.1 RNA chaperone Hfq -
M3707_RS01785 (M3707_01785) 348890..349843 - 954 WP_006250325.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
M3707_RS01790 (M3707_01790) 350283..350549 + 267 WP_006250323.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3707_RS01795 (M3707_01795) 350536..350805 + 270 WP_006250322.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
M3707_RS01800 (M3707_01800) 350824..352707 - 1884 WP_006250321.1 DNA mismatch repair endonuclease MutL -
M3707_RS01805 (M3707_01805) 352991..354229 + 1239 WP_006250320.1 glutamate-5-semialdehyde dehydrogenase -
M3707_RS01810 (M3707_01810) 354231..355076 + 846 WP_006250319.1 virulence factor BrkB family protein -
M3707_RS01815 (M3707_01815) 355051..355485 + 435 WP_006250318.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10447.99 Da        Isoelectric Point: 6.4732

>T245183 WP_006250322.1 NZ_CP097334:350536-350805 [Mannheimia haemolytica]
MREIEYSNAFKRDYKKCAVESLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKVEDDKLELLR
IGSHSHLFG

Download         Length: 270 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9738.10 Da        Isoelectric Point: 4.7954

>AT245183 WP_006250323.1 NZ_CP097334:350283-350549 [Mannheimia haemolytica]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNFETAEVLRAVKNGEEKLHSANSIADL
MEQLNARD

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZX63

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZY54

References