Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 77548..78263 Replicon chromosome
Accession NZ_CP097334
Organism Mannheimia haemolytica strain 183

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M3707_RS00390 Protein ID WP_006250491.1
Coordinates 77548..77976 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A248ZW87
Locus tag M3707_RS00395 Protein ID WP_006248272.1
Coordinates 77976..78263 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3707_RS00375 (M3707_00375) 72802..74454 + 1653 WP_006248275.1 phospho-sugar mutase -
M3707_RS00380 (M3707_00380) 74507..75441 + 935 Protein_75 nucleoside hydrolase -
M3707_RS00385 (M3707_00385) 75463..77544 - 2082 WP_006248274.1 ATP-dependent DNA helicase RecG -
M3707_RS00390 (M3707_00390) 77548..77976 - 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
M3707_RS00395 (M3707_00395) 77976..78263 - 288 WP_006248272.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M3707_RS00400 (M3707_00400) 78427..80310 + 1884 WP_006248270.1 molecular chaperone HtpG -
M3707_RS00405 (M3707_00405) 80363..80524 + 162 WP_015483997.1 hypothetical protein -
M3707_RS00410 (M3707_00410) 80688..82403 + 1716 WP_006248268.1 proline--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T245181 WP_006250491.1 NZ_CP097334:c77976-77548 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11085.39 Da        Isoelectric Point: 4.3648

>AT245181 WP_006248272.1 NZ_CP097334:c78263-77976 [Mannheimia haemolytica]
MAITITSREFNQNASKVLKMAEKEPVFITKWGKIVNVVSSYMDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVE
IRKSNKPRPVDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZW87

References