Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 739514..740036 Replicon chromosome
Accession NZ_CP097333
Organism Mannheimia haemolytica strain 184

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag M3709_RS03745 Protein ID WP_006249269.1
Coordinates 739514..739810 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag M3709_RS03750 Protein ID WP_006249270.1
Coordinates 739794..740036 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3709_RS03730 (M3709_03730) 734568..735893 + 1326 WP_020831251.1 anti-phage deoxyguanosine triphosphatase -
M3709_RS03735 (M3709_03735) 736014..736313 + 300 WP_006249265.1 hypothetical protein -
M3709_RS03740 (M3709_03740) 736475..739387 + 2913 WP_006249267.1 RNA polymerase-associated protein RapA -
M3709_RS03745 (M3709_03745) 739514..739810 + 297 WP_006249269.1 BrnT family toxin Toxin
M3709_RS03750 (M3709_03750) 739794..740036 + 243 WP_006249270.1 CopG family antitoxin Antitoxin
M3709_RS03755 (M3709_03755) 740048..740716 + 669 WP_006249271.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
M3709_RS03760 (M3709_03760) 740694..741269 - 576 WP_006249272.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
M3709_RS03765 (M3709_03765) 741329..742171 + 843 WP_006250575.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
M3709_RS03770 (M3709_03770) 742294..742935 + 642 WP_040080687.1 orotate phosphoribosyltransferase -
M3709_RS03775 (M3709_03775) 743109..744186 + 1078 Protein_715 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T245178 WP_006249269.1 NZ_CP097333:739514-739810 [Mannheimia haemolytica]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT245178 WP_006249270.1 NZ_CP097333:739794-740036 [Mannheimia haemolytica]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249A107

Antitoxin

Source ID Structure
AlphaFold DB A0A249A190

References