Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 313330..313852 Replicon chromosome
Accession NZ_CP097333
Organism Mannheimia haemolytica strain 184

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M3709_RS01590 Protein ID WP_040080572.1
Coordinates 313330..313599 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A248ZY54
Locus tag M3709_RS01595 Protein ID WP_006250323.1
Coordinates 313586..313852 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3709_RS01570 (M3709_01570) 308650..309084 - 435 WP_006250318.1 D-aminoacyl-tRNA deacylase -
M3709_RS01575 (M3709_01575) 309059..309904 - 846 WP_006251985.1 virulence factor BrkB family protein -
M3709_RS01580 (M3709_01580) 309906..311144 - 1239 WP_006251984.1 glutamate-5-semialdehyde dehydrogenase -
M3709_RS01585 (M3709_01585) 311428..313311 + 1884 WP_040080571.1 DNA mismatch repair endonuclease MutL -
M3709_RS01590 (M3709_01590) 313330..313599 - 270 WP_040080572.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
M3709_RS01595 (M3709_01595) 313586..313852 - 267 WP_006250323.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3709_RS01600 (M3709_01600) 314292..315245 + 954 WP_040080573.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
M3709_RS01605 (M3709_01605) 315314..315586 + 273 WP_006250326.1 RNA chaperone Hfq -
M3709_RS01610 (M3709_01610) 315606..316991 + 1386 WP_006251981.1 GTPase HflX -
M3709_RS01615 (M3709_01615) 317329..318369 + 1041 WP_040080511.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10508.09 Da        Isoelectric Point: 6.4732

>T245177 WP_040080572.1 NZ_CP097333:c313599-313330 [Mannheimia haemolytica]
MREIEYSNAFKRDYKKCAVEFLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKVEDDKLELLR
IGSHSHLFG

Download         Length: 270 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9738.10 Da        Isoelectric Point: 4.7954

>AT245177 WP_006250323.1 NZ_CP097333:c313852-313586 [Mannheimia haemolytica]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNFETAEVLRAVKNGEEKLHSANSIADL
MEQLNARD

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZY54

References