Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 53327..54042 Replicon chromosome
Accession NZ_CP097333
Organism Mannheimia haemolytica strain 184

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M3709_RS00245 Protein ID WP_006250491.1
Coordinates 53327..53755 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A248ZW87
Locus tag M3709_RS00250 Protein ID WP_006248272.1
Coordinates 53755..54042 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3709_RS00230 (M3709_00230) 48582..50234 + 1653 WP_040080487.1 phospho-sugar mutase -
M3709_RS00235 (M3709_00235) 50287..51220 + 934 Protein_46 nucleoside hydrolase -
M3709_RS00240 (M3709_00240) 51242..53323 - 2082 WP_040080489.1 ATP-dependent DNA helicase RecG -
M3709_RS00245 (M3709_00245) 53327..53755 - 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
M3709_RS00250 (M3709_00250) 53755..54042 - 288 WP_006248272.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M3709_RS00255 (M3709_00255) 54206..56089 + 1884 WP_040080490.1 molecular chaperone HtpG -
M3709_RS00260 (M3709_00260) 56178..56324 + 147 WP_230269068.1 hypothetical protein -
M3709_RS00265 (M3709_00265) 56469..57509 + 1041 WP_040080492.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 56469..57509 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T245175 WP_006250491.1 NZ_CP097333:c53755-53327 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11085.39 Da        Isoelectric Point: 4.3648

>AT245175 WP_006248272.1 NZ_CP097333:c54042-53755 [Mannheimia haemolytica]
MAITITSREFNQNASKVLKMAEKEPVFITKWGKIVNVVSSYMDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVE
IRKSNKPRPVDFGDE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A248ZW87

References