Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3487901..3488580 Replicon chromosome
Accession NZ_CP097330
Organism Cupriavidus campinensis strain G5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5D45_RS16510 Protein ID WP_144202030.1
Coordinates 3487901..3488329 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M5D45_RS16515 Protein ID WP_144202032.1
Coordinates 3488326..3488580 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5D45_RS16490 (M5D45_16490) 3484265..3485116 - 852 WP_144202020.1 hypothetical protein -
M5D45_RS16495 (M5D45_16495) 3485322..3485948 + 627 WP_211943605.1 DNA-3-methyladenine glycosylase I -
M5D45_RS16500 (M5D45_16500) 3486357..3486986 + 630 WP_144202025.1 LysE family translocator -
M5D45_RS16505 (M5D45_16505) 3486942..3487904 - 963 WP_144202028.1 cation diffusion facilitator family transporter -
M5D45_RS16510 (M5D45_16510) 3487901..3488329 - 429 WP_144202030.1 type II toxin-antitoxin system VapC family toxin Toxin
M5D45_RS16515 (M5D45_16515) 3488326..3488580 - 255 WP_144202032.1 Arc family DNA-binding protein Antitoxin
M5D45_RS16525 (M5D45_16525) 3488887..3490608 - 1722 WP_250024873.1 thiosulfohydrolase SoxB -
M5D45_RS16530 (M5D45_16530) 3490628..3491332 - 705 WP_250024874.1 sulfur oxidation c-type cytochrome SoxX -
M5D45_RS16535 (M5D45_16535) 3491350..3492189 - 840 WP_144202059.1 sulfur oxidation c-type cytochrome SoxA -
M5D45_RS16540 (M5D45_16540) 3492322..3492795 - 474 WP_144202061.1 DsrE family protein -
M5D45_RS16545 (M5D45_16545) 3492818..3493129 - 312 WP_092300146.1 thiosulfate oxidation carrier complex protein SoxZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(6-46)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15103.36 Da        Isoelectric Point: 6.2243

>T245173 WP_144202030.1 NZ_CP097330:c3488329-3487901 [Cupriavidus campinensis]
MIVLDTNVVSEAMKPEPNPAVRAWLNAQVAETLYLSSVTLAELLFGIGALPEGRRKHGLSETLDGLLALFGDRVLMFDTG
AARHYAELAVKARLAGKGFPTPDGYIGAIAASRGYIVATRDTAPFEAAGLTVINPWNHSSIP

Download         Length: 429 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9491.79 Da        Isoelectric Point: 6.4732

>AT245173 WP_144202032.1 NZ_CP097330:c3488580-3488326 [Cupriavidus campinensis]
MPMLTVRNVPDEVHRALRMRAAEHGRSTEAEVREILERAVKSEQRVRMGDALAALGQRAGLTNDDFAVFDTQRDKAPAEP
MKFE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References