Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2106090..2106667 Replicon chromosome
Accession NZ_CP097327
Organism Providencia vermicola strain P13

Toxin (Protein)


Gene name mazF Uniprot ID U5N651
Locus tag M5J11_RS09590 Protein ID WP_023159957.1
Coordinates 2106335..2106667 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag M5J11_RS09585 Protein ID WP_096864992.1
Coordinates 2106090..2106335 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5J11_RS09555 (M5J11_09555) 2101264..2102301 + 1038 Protein_1835 IS630-like element ISAeme16 family transposase -
M5J11_RS09570 (M5J11_09570) 2104462..2104755 + 294 WP_101135438.1 hypothetical protein -
M5J11_RS09575 (M5J11_09575) 2104853..2105080 - 228 WP_096864993.1 plasmid partition protein ParG -
M5J11_RS09580 (M5J11_09580) 2105197..2105820 - 624 WP_023159958.1 AAA family ATPase -
M5J11_RS09585 (M5J11_09585) 2106090..2106335 + 246 WP_096864992.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M5J11_RS09590 (M5J11_09590) 2106335..2106667 + 333 WP_023159957.1 endoribonuclease MazF Toxin
M5J11_RS09595 (M5J11_09595) 2106698..2107078 + 381 WP_096864991.1 hypothetical protein -
M5J11_RS09600 (M5J11_09600) 2107164..2107307 - 144 WP_071547955.1 Hok/Gef family protein -
M5J11_RS09610 (M5J11_09610) 2108013..2109181 + 1169 WP_166685554.1 IS3 family transposase -
M5J11_RS09615 (M5J11_09615) 2109188..2109520 + 333 Protein_1845 glycosyltransferase -
M5J11_RS09620 (M5J11_09620) 2109601..2110767 + 1167 WP_251465220.1 nucleotide sugar dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ugd / ugd 2074594..2124332 49738
- inside IScluster/Tn - ugd 2097885..2109181 11296


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12097.88 Da        Isoelectric Point: 7.0813

>T245158 WP_023159957.1 NZ_CP097327:2106335-2106667 [Providencia vermicola]
MVSRYVPDSGDLIWIDFDPVEGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTKGKGYPFECELSNERDSYALADQVTCV
DWRARKVTKKGKVEASELAEIKAKAKALIG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8800.23 Da        Isoelectric Point: 5.0508

>AT245158 WP_096864992.1 NZ_CP097327:2106090-2106335 [Providencia vermicola]
MAQVTVKKWGNSPSVRLPVAIMQKAALSVDDTVEIAVEEGRIIITPVKAVEYSLENLLAGITPENIHEKVDFGARTGKEL
I

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P1BQ75

Antitoxin

Source ID Structure

References