Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1946903..1947553 Replicon chromosome
Accession NZ_CP097327
Organism Providencia vermicola strain P13

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag M5J11_RS08915 Protein ID WP_004927064.1
Coordinates 1946903..1947106 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag M5J11_RS08920 Protein ID WP_154635730.1
Coordinates 1947185..1947553 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5J11_RS08890 (M5J11_08890) 1942783..1943121 + 339 WP_154622397.1 P-II family nitrogen regulator -
M5J11_RS08895 (M5J11_08895) 1943132..1944415 + 1284 WP_251465118.1 ammonium transporter AmtB -
M5J11_RS08900 (M5J11_08900) 1944643..1945509 - 867 WP_251465121.1 acyl-CoA thioesterase II -
M5J11_RS08905 (M5J11_08905) 1945834..1946292 + 459 WP_251465123.1 YbaY family lipoprotein -
M5J11_RS08915 (M5J11_08915) 1946903..1947106 - 204 WP_004927064.1 HHA domain-containing protein Toxin
M5J11_RS08920 (M5J11_08920) 1947185..1947553 - 369 WP_154635730.1 Hha toxicity modulator TomB Antitoxin
M5J11_RS08925 (M5J11_08925) 1948121..1949458 - 1338 WP_154624041.1 murein transglycosylase D -
M5J11_RS08930 (M5J11_08930) 1949537..1950292 - 756 WP_154624042.1 hydroxyacylglutathione hydrolase -
M5J11_RS08935 (M5J11_08935) 1950332..1951057 + 726 WP_154624043.1 methyltransferase domain-containing protein -
M5J11_RS08940 (M5J11_08940) 1951124..1951594 - 471 WP_154624044.1 ribonuclease HI -
M5J11_RS08945 (M5J11_08945) 1951649..1952410 + 762 WP_154624045.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T245157 WP_004927064.1 NZ_CP097327:c1947106-1946903 [Providencia vermicola]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14106.92 Da        Isoelectric Point: 4.3486

>AT245157 WP_154635730.1 NZ_CP097327:c1947553-1947185 [Providencia vermicola]
MDEYSPKNYDISELKYLCNSLNREAISSLQKTNTHWINDLSSPQSVRLNELIEHIAAFVWQYKIKHPKDNLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVAVLDDDLKCPASKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure

References