245156

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 983341..985070 Replicon chromosome
Accession NZ_CP097327
Organism Providencia vermicola strain P13

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag M5J11_RS04740 Protein ID WP_154623506.1
Coordinates 983341..983985 (+) Length 215 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag M5J11_RS04745 Protein ID WP_154623505.1
Coordinates 983997..985070 (+) Length 358 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5J11_RS04725 (M5J11_04725) 980927..981757 + 831 WP_154624783.1 formate dehydrogenase accessory sulfurtransferase FdhD -
M5J11_RS04730 (M5J11_04730) 981761..982540 - 780 WP_154624784.1 transferase -
M5J11_RS04735 (M5J11_04735) 982772..983341 + 570 WP_154623507.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -
M5J11_RS04740 (M5J11_04740) 983341..983985 + 645 WP_154623506.1 DUF4433 domain-containing protein Toxin
M5J11_RS04745 (M5J11_04745) 983997..985070 + 1074 WP_154623505.1 macro domain-containing protein Antitoxin
M5J11_RS04750 (M5J11_04750) 985299..985928 - 630 WP_001145449.1 hypothetical protein -
M5J11_RS04755 (M5J11_04755) 986071..986136 + 66 Protein_900 EAL domain-containing protein -
M5J11_RS04760 (M5J11_04760) 986276..987040 - 765 WP_001389365.1 IS6-like element IS6100 family transposase -
M5J11_RS04770 (M5J11_04770) 987547..988047 - 501 WP_000376623.1 GNAT family N-acetyltransferase -
M5J11_RS04775 (M5J11_04775) 988175..989014 - 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -
M5J11_RS04780 (M5J11_04780) 989008..989355 - 348 WP_112040837.1 quaternary ammonium compound efflux SMR transporter QacE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element sul1 / qacE / lnu(F) / aadA2 / floR / sul2 / aph(4)-Ia / aac(3)-IVa / aph(3')-Ia / msr(E) / mph(E) / blaNDM-1 / dfrA1 / ant(3'')-Ia / blaOXA-10 / catB8 / ant(2'')-Ia rfaD / ugd 830188..1088753 258565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-214)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 25047.66 Da        Isoelectric Point: 6.9106

>T245156 WP_154623506.1 NZ_CP097327:983341-983985 [Providencia vermicola]
MAYMNLNPEKALIWRITHRQNIPWLFANGLYAGNSEHYSPNWVTIGNTDLINRRNQRHVPIQPNGVLNDYVPFYFTPFSP
MMYNIYTGRGGVRKVPNDDIIILVSSMYKIAALKIPFVFTDRHAYPVTSQFYNQLTDLAEIDWALLQQRNFHRDPDDPEK
VERYQAEALIYKHVPMEALLGAVCYTKETQLELQAKASQLEIHLDIHCIPNWYF

Download         Length: 645 bp

Antitoxin


Download         Length: 358 a.a.        Molecular weight: 40807.28 Da        Isoelectric Point: 7.8198

>AT245156 WP_154623505.1 NZ_CP097327:983997-985070 [Providencia vermicola]
MIEFTQGNLLEADVEALVNTVNTVGVMGKGIALMFKERFPANMAAYAKACKTHEVQTGKMFVTETGELMGPRWIVNFPTK
QHWRAKSQIQWIIDGLLDLRNFIEENHVKSIAIPPLGAGNGGLNWDDVKPHIVEILGDIQNVKIIVYEPIAKYQNVAKPK
GVEKLTPARALIAELIRRYWVMGMDCSLLEIQKLAWFLERTIEAEGLRNPLNLRFEARNYGPYADKLRHLLNGLDGSYLK
SEKRISDCSPLDVIWFNDDKRATIELYLKTEAKDYLSALEKTTKLIDGFESPFGIELLSTVDWLLYKKQSSPNIESLLEG
MRQWPAGDRWAQRKLRLFDSNKLELALNHLKQIPFYS

Download         Length: 1074 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References