245154

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1281844..1282761 Replicon chromosome
Accession NZ_CP097326
Organism Bacillus velezensis strain GUCC45

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6A8LGT8
Locus tag M5J22_RS06645 Protein ID WP_003154806.1
Coordinates 1282015..1282761 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID -
Locus tag M5J22_RS06640 Protein ID WP_060386896.1
Coordinates 1281844..1282014 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5J22_RS06600 (M5J22_06600) 1277056..1278645 + 1590 WP_029973066.1 hypothetical protein -
M5J22_RS06605 (M5J22_06605) 1278658..1279083 + 426 WP_029973065.1 hypothetical protein -
M5J22_RS06610 (M5J22_06610) 1279088..1279285 + 198 WP_007610833.1 XkdX family protein -
M5J22_RS06615 (M5J22_06615) 1279342..1280103 + 762 WP_024085194.1 hypothetical protein -
M5J22_RS06620 (M5J22_06620) 1280155..1280418 + 264 WP_032866112.1 hemolysin XhlA family protein -
M5J22_RS06625 (M5J22_06625) 1280432..1280695 + 264 WP_003154813.1 phage holin -
M5J22_RS06630 (M5J22_06630) 1280709..1281587 + 879 WP_024085195.1 N-acetylmuramoyl-L-alanine amidase -
M5J22_RS06635 (M5J22_06635) 1281622..1281747 - 126 WP_003154809.1 hypothetical protein -
M5J22_RS06640 (M5J22_06640) 1281844..1282014 - 171 WP_060386896.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M5J22_RS06645 (M5J22_06645) 1282015..1282761 - 747 WP_003154806.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M5J22_RS06650 (M5J22_06650) 1282866..1283864 - 999 WP_003154805.1 inorganic phosphate transporter -
M5J22_RS06655 (M5J22_06655) 1283877..1284494 - 618 WP_003154804.1 DUF47 domain-containing protein -
M5J22_RS06660 (M5J22_06660) 1284780..1286096 - 1317 WP_046559522.1 amino acid permease -
M5J22_RS06665 (M5J22_06665) 1286420..1287370 + 951 WP_060386897.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1247473..1340003 92530


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29034.50 Da        Isoelectric Point: 4.6947

>T245154 WP_003154806.1 NZ_CP097326:c1282761-1282015 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6666.70 Da        Isoelectric Point: 10.9273

>AT245154 WP_060386896.1 NZ_CP097326:c1282014-1281844 [Bacillus velezensis]
MEQAFQNGQPEQRAKSFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A8LGT8

Antitoxin

Source ID Structure

References