Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4589015..4589550 Replicon chromosome
Accession NZ_CP097324
Organism Citrobacter sp. XT1-2-2 strain XT1_2_2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M4I31_RS21820 Protein ID WP_085049650.1
Coordinates 4589263..4589550 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4BKM9
Locus tag M4I31_RS21815 Protein ID WP_006688247.1
Coordinates 4589015..4589266 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4I31_RS21785 (4584508) 4584508..4585266 + 759 WP_085049653.1 phosphonate C-P lyase system protein PhnK -
M4I31_RS21790 (4585374) 4585374..4586054 + 681 WP_069325130.1 phosphonate C-P lyase system protein PhnL -
M4I31_RS21795 (4586051) 4586051..4587187 + 1137 WP_085049652.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
M4I31_RS21800 (4587190) 4587190..4587744 + 555 WP_038636371.1 ribose 1,5-bisphosphokinase -
M4I31_RS21805 (4587731) 4587731..4588165 + 435 WP_038636367.1 aminoalkylphosphonate N-acetyltransferase -
M4I31_RS21810 (4588174) 4588174..4588932 + 759 WP_085049651.1 phosphonate metabolism protein PhnP -
M4I31_RS21815 (4589015) 4589015..4589266 + 252 WP_006688247.1 plasmid stabilization protein Antitoxin
M4I31_RS21820 (4589263) 4589263..4589550 + 288 WP_085049650.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4I31_RS21825 (4589547) 4589547..4589876 - 330 WP_069325126.1 DDRRRQL repeat protein YjdP -
M4I31_RS21830 (4589946) 4589946..4592210 - 2265 WP_085049649.1 hybrid sensor histidine kinase/response regulator -
M4I31_RS21835 (4592325) 4592325..4593848 + 1524 WP_069325124.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11089.04 Da        Isoelectric Point: 10.3527

>T245151 WP_085049650.1 NZ_CP097324:4589263-4589550 [Citrobacter sp. XT1-2-2]
MSYTVKFREDALKEWQKLDKAIQQQFAKKLKKCCENPHVPSAKLRGIKDCYKIKLRTSGFRLVYQVIDDTLVIAVVAVGK
RERSEVYNLASERLR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9215.53 Da        Isoelectric Point: 4.2965

>AT245151 WP_006688247.1 NZ_CP097324:4589015-4589266 [Citrobacter sp. XT1-2-2]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7X1BT32

References