Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2488117..2488874 Replicon chromosome
Accession NZ_CP097324
Organism Citrobacter sp. XT1-2-2 strain XT1_2_2

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag M4I31_RS11790 Protein ID WP_085048216.1
Coordinates 2488392..2488874 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A2Z3X7E0
Locus tag M4I31_RS11785 Protein ID WP_038640582.1
Coordinates 2488117..2488401 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4I31_RS11755 (2483169) 2483169..2483567 - 399 WP_085048211.1 ion channel -
M4I31_RS11760 (2483779) 2483779..2484417 + 639 WP_085048212.1 helix-turn-helix domain-containing protein -
M4I31_RS11765 (2484579) 2484579..2484893 + 315 WP_085048213.1 helix-turn-helix transcriptional regulator -
M4I31_RS11770 (2484886) 2484886..2486157 + 1272 WP_085048214.1 type II toxin-antitoxin system HipA family toxin -
M4I31_RS11775 (2486195) 2486195..2487562 - 1368 WP_085048215.1 glycoside hydrolase family 10 protein -
M4I31_RS11780 (2487575) 2487575..2487862 - 288 WP_079224212.1 VF530 family protein -
M4I31_RS11785 (2488117) 2488117..2488401 + 285 WP_038640582.1 DUF1778 domain-containing protein Antitoxin
M4I31_RS11790 (2488392) 2488392..2488874 + 483 WP_085048216.1 GNAT family N-acetyltransferase Toxin
M4I31_RS11795 (2488897) 2488897..2489154 - 258 WP_233638873.1 AraC family transcriptional regulator -
M4I31_RS11800 (2489144) 2489144..2489194 - 51 Protein_2309 hypothetical protein -
M4I31_RS11805 (2489528) 2489528..2490799 - 1272 WP_085048217.1 general secretion pathway protein GspD -
M4I31_RS11810 (2491056) 2491056..2491838 - 783 WP_176281255.1 zonular occludens toxin domain-containing protein -
M4I31_RS11815 (2491840) 2491840..2492178 - 339 WP_085048218.1 DUF5455 family protein -
M4I31_RS11820 (2492180) 2492180..2493172 - 993 WP_085048219.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-148)

Antitoxin

Vibrio phage ICP1, Orf50

(13-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17813.50 Da        Isoelectric Point: 7.7963

>T245148 WP_085048216.1 NZ_CP097324:2488392-2488874 [Citrobacter sp. XT1-2-2]
MEINVTTPVLLTEGHDLQPFDCGNDVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDVCTQGHSFGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10998.45 Da        Isoelectric Point: 7.0152

>AT245148 WP_038640582.1 NZ_CP097324:2488117-2488401 [Citrobacter sp. XT1-2-2]
MQSSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAPVQNV
EGRQRLMNVKPEWK

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z3X7E0

References