Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2391765..2392404 Replicon chromosome
Accession NZ_CP097324
Organism Citrobacter sp. XT1-2-2 strain XT1_2_2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M4I31_RS11350 Protein ID WP_085048165.1
Coordinates 2391765..2391941 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M4I31_RS11355 Protein ID WP_139815562.1
Coordinates 2391988..2392404 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4I31_RS11330 (2388543) 2388543..2388773 - 231 WP_038640744.1 DUF2554 family protein -
M4I31_RS11335 (2388963) 2388963..2389088 - 126 WP_064507023.1 DUF2474 domain-containing protein -
M4I31_RS11340 (2389088) 2389088..2390098 - 1011 WP_085048163.1 cytochrome d ubiquinol oxidase subunit II -
M4I31_RS11345 (2390098) 2390098..2391501 - 1404 WP_085048164.1 cytochrome ubiquinol oxidase subunit I -
M4I31_RS11350 (2391765) 2391765..2391941 + 177 WP_085048165.1 type II toxin-antitoxin system HicA family toxin Toxin
M4I31_RS11355 (2391988) 2391988..2392404 + 417 WP_139815562.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M4I31_RS11360 (2392497) 2392497..2393906 + 1410 WP_038640734.1 PLP-dependent aminotransferase family protein -
M4I31_RS11365 (2394236) 2394236..2395381 + 1146 WP_069324934.1 ABC transporter substrate-binding protein -
M4I31_RS11370 (2395398) 2395398..2396414 + 1017 WP_085048167.1 ABC transporter ATP-binding protein -
M4I31_RS11375 (2396415) 2396415..2397359 + 945 WP_069324933.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6783.83 Da        Isoelectric Point: 11.6208

>T245147 WP_085048165.1 NZ_CP097324:2391765-2391941 [Citrobacter sp. XT1-2-2]
VKQSEFRRWLESQGVKVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIQKQLGLQ

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15092.41 Da        Isoelectric Point: 4.5468

>AT245147 WP_139815562.1 NZ_CP097324:2391988-2392404 [Citrobacter sp. XT1-2-2]
MRYPVNLIPAVEGGFMVSFPDIPEALTQGETRHDALQAAQAALVTAFEFYFDDNEPIPLPSAVVAGADYVEIPLSVASKV
LLLNAFLESNITQQELANRIGRPKQEITRLFDLKHATKIDVVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References