Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 852378..853032 Replicon chromosome
Accession NZ_CP097324
Organism Citrobacter sp. XT1-2-2 strain XT1_2_2

Toxin (Protein)


Gene name cptA Uniprot ID A0A2Z3X2B8
Locus tag M4I31_RS04165 Protein ID WP_038633481.1
Coordinates 852625..853032 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag M4I31_RS04160 Protein ID WP_016154349.1
Coordinates 852378..852644 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4I31_RS04135 (847580) 847580..849013 - 1434 WP_038633498.1 6-phospho-beta-glucosidase BglA -
M4I31_RS04140 (849134) 849134..849862 - 729 WP_085048762.1 MurR/RpiR family transcriptional regulator -
M4I31_RS04145 (849915) 849915..850226 + 312 WP_085048763.1 N(4)-acetylcytidine aminohydrolase -
M4I31_RS04150 (850390) 850390..851049 + 660 WP_038633489.1 hemolysin III family protein -
M4I31_RS04155 (851141) 851141..852121 - 981 WP_085048764.1 tRNA-modifying protein YgfZ -
M4I31_RS04160 (852378) 852378..852644 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
M4I31_RS04165 (852625) 852625..853032 + 408 WP_038633481.1 protein YgfX Toxin
M4I31_RS04170 (853133) 853133..853654 - 522 WP_038633478.1 flavodoxin FldB -
M4I31_RS04175 (853768) 853768..854664 + 897 WP_038633475.1 site-specific tyrosine recombinase XerD -
M4I31_RS04180 (854688) 854688..855401 + 714 WP_061382414.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M4I31_RS04185 (855407) 855407..857140 + 1734 WP_085048766.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15944.81 Da        Isoelectric Point: 11.2845

>T245142 WP_038633481.1 NZ_CP097324:852625-853032 [Citrobacter sp. XT1-2-2]
VVQWQSDLRVSWRAQWLSLLVHGLVAVFILLMPWPLSYTPLWMVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIVSAPWMVKTGMMLRLRSDTGKRQHLWLAADSMDEAEWRDLRRLMLQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT245142 WP_016154349.1 NZ_CP097324:852378-852644 [Citrobacter sp. XT1-2-2]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z3X2B8

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References