Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 4620947..4621460 Replicon chromosome
Accession NZ_CP097322
Organism Streptomyces sp. RerS4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M4D82_RS21590 Protein ID WP_249767606.1
Coordinates 4620947..4621210 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M4D82_RS21595 Protein ID WP_249772027.1
Coordinates 4621203..4621460 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4D82_RS21560 (M4D82_21560) 4616111..4617127 + 1017 WP_249767602.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
M4D82_RS21565 (M4D82_21565) 4617221..4617964 + 744 WP_249767603.1 ROK family protein -
M4D82_RS21570 (M4D82_21570) 4618038..4618448 - 411 Protein_4241 hypothetical protein -
M4D82_RS21575 (M4D82_21575) 4618599..4619687 + 1089 WP_249767604.1 redox-regulated ATPase YchF -
M4D82_RS21580 (M4D82_21580) 4619781..4620362 - 582 WP_249767605.1 Uma2 family endonuclease -
M4D82_RS21585 (M4D82_21585) 4620409..4620933 + 525 Protein_4244 hypothetical protein -
M4D82_RS21590 (M4D82_21590) 4620947..4621210 - 264 WP_249767606.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4D82_RS21595 (M4D82_21595) 4621203..4621460 - 258 WP_249772027.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M4D82_RS21600 (M4D82_21600) 4621653..4622822 - 1170 WP_249767607.1 hypothetical protein -
M4D82_RS21605 (M4D82_21605) 4622953..4623444 + 492 WP_249767608.1 cupin domain-containing protein -
M4D82_RS21610 (M4D82_21610) 4623507..4623872 + 366 WP_249767609.1 hypothetical protein -
M4D82_RS21615 (M4D82_21615) 4623876..4624877 - 1002 WP_249767610.1 SMP-30/gluconolactonase/LRE family protein -
M4D82_RS21620 (M4D82_21620) 4624953..4625390 + 438 WP_249767611.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10002.40 Da        Isoelectric Point: 7.4018

>T245141 WP_249767606.1 NZ_CP097322:c4621210-4620947 [Streptomyces sp. RerS4]
VSEYRTVFRPEAQAELRKVPRDMALRILAKLTELESDPLGFNTTALVSQPDRRRLRFGDHRVVYAIDSGELVVWVVHVGH
HSTIYDT

Download         Length: 264 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9693.01 Da        Isoelectric Point: 4.5008

>AT245141 WP_249772027.1 NZ_CP097322:c4621460-4621203 [Streptomyces sp. RerS4]
MPIESVRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDVMGET
LARGE

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References