Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 2856812..2857377 Replicon chromosome
Accession NZ_CP097322
Organism Streptomyces sp. RerS4

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag M4D82_RS13150 Protein ID WP_249766236.1
Coordinates 2856812..2857183 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A024YMK9
Locus tag M4D82_RS13155 Protein ID WP_037923309.1
Coordinates 2857180..2857377 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4D82_RS13130 (M4D82_13130) 2851846..2852643 - 798 WP_249766233.1 S16 family serine protease -
M4D82_RS13135 (M4D82_13135) 2852723..2853364 - 642 WP_053684560.1 helix-turn-helix domain-containing protein -
M4D82_RS13140 (M4D82_13140) 2853733..2854809 + 1077 WP_249766234.1 hypothetical protein -
M4D82_RS13145 (M4D82_13145) 2854889..2856676 - 1788 WP_249766235.1 DEAD/DEAH box helicase -
M4D82_RS13150 (M4D82_13150) 2856812..2857183 - 372 WP_249766236.1 Fic family protein Toxin
M4D82_RS13155 (M4D82_13155) 2857180..2857377 - 198 WP_037923309.1 Arc family DNA-binding protein Antitoxin
M4D82_RS13160 (M4D82_13160) 2857411..2858901 - 1491 WP_249766237.1 MFS transporter -
M4D82_RS13165 (M4D82_13165) 2859023..2861347 - 2325 WP_249766238.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-81)

Antitoxin

Arc-like DNA binding domain

(5-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13637.45 Da        Isoelectric Point: 4.4983

>T245140 WP_249766236.1 NZ_CP097322:c2857183-2856812 [Streptomyces sp. RerS4]
MTHYLTLPELLNLAERLGANEVRDYGLLDSALARPQASVFGQDAYPDVWQKAAALMESLARNHGLVDGNKRIAWYATWVF
LHMNGHPLDADFDVDEAEQFVLDVCQGALDVPKIAAQLPRFAG

Download         Length: 372 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7321.19 Da        Isoelectric Point: 5.6050

>AT245140 WP_037923309.1 NZ_CP097322:c2857377-2857180 [Streptomyces sp. RerS4]
MAGLNVRFTEEELDALRERAEAEGRSMQSFAHDAVIKAINEHSRLFNEAAEHVLKASAELNRRLA

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A024YMK9

References