245138

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3901676..3902196 Replicon chromosome
Accession NZ_CP097320
Organism Candidatus Mycobacterium methanotrophicum isolate Sulfur Cave

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M5I08_RS20430 Protein ID WP_249762933.1
Coordinates 3901912..3902196 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M5I08_RS20425 Protein ID WP_219070811.1
Coordinates 3901676..3901915 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5I08_RS20390 (M5I08_20390) 3896927..3897451 - 525 WP_219068056.1 restriction endonuclease -
M5I08_RS20395 (M5I08_20395) 3897812..3899038 + 1227 WP_249763288.1 IS110 family transposase -
M5I08_RS20400 (M5I08_20400) 3899074..3899337 - 264 WP_219070814.1 type II toxin-antitoxin system RelE/ParE family toxin -
M5I08_RS20405 (M5I08_20405) 3899334..3899618 - 285 WP_219070813.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M5I08_RS20410 (M5I08_20410) 3899735..3900215 + 481 Protein_4055 peroxiredoxin -
M5I08_RS20415 (M5I08_20415) 3900349..3900665 + 317 Protein_4056 DUF742 domain-containing protein -
M5I08_RS20420 (M5I08_20420) 3900740..3901387 + 648 WP_249763461.1 hypothetical protein -
M5I08_RS20425 (M5I08_20425) 3901676..3901915 + 240 WP_219070811.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M5I08_RS20430 (M5I08_20430) 3901912..3902196 + 285 WP_249762933.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5I08_RS20435 (M5I08_20435) 3902408..3903365 + 958 Protein_4060 transposase -
M5I08_RS20440 (M5I08_20440) 3903444..3903680 - 237 Protein_4061 cytochrome P450 -
M5I08_RS20445 (M5I08_20445) 3904269..3904454 + 186 WP_219070903.1 hypothetical protein -
M5I08_RS20450 (M5I08_20450) 3904606..3905832 - 1227 WP_249763285.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(12-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10585.23 Da        Isoelectric Point: 11.5314

>T245138 WP_249762933.1 NZ_CP097320:3901912-3902196 [Candidatus Mycobacterium methanotrophicum]
VSSAPTDPYELRITPEGLRHLNRLPAKIRDAALAALHGPIRENPHRLGRALVGELAGLFSARRGDYRIIYSIDDTAKIVI
VHRIAHRASVYRRR

Download         Length: 285 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8820.94 Da        Isoelectric Point: 4.8550

>AT245138 WP_219070811.1 NZ_CP097320:3901676-3901915 [Candidatus Mycobacterium methanotrophicum]
MPFSEAKAHLSELAERVELEHARVLVTRNGRPSFVLVSPDDLDALEETLDILRDRELVASLKRSQEEAAQGRSRPLPSA

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References