245127

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1664866..1665548 Replicon chromosome
Accession NZ_CP097320
Organism Candidatus Mycobacterium methanotrophicum isolate Sulfur Cave

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5I08_RS08990 Protein ID WP_219067311.1
Coordinates 1665120..1665548 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M5I08_RS08985 Protein ID WP_219067310.1
Coordinates 1664866..1665123 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5I08_RS08960 (M5I08_08960) 1660274..1660789 + 516 WP_219067305.1 5-(carboxyamino)imidazole ribonucleotide mutase -
M5I08_RS08965 (M5I08_08965) 1660866..1662035 + 1170 WP_219067306.1 acyl-CoA dehydrogenase -
M5I08_RS08970 (M5I08_08970) 1662129..1662467 - 339 WP_219067307.1 hypothetical protein -
M5I08_RS08975 (M5I08_08975) 1662546..1663733 - 1188 WP_219067308.1 CoA transferase -
M5I08_RS08980 (M5I08_08980) 1663733..1664644 - 912 WP_219067309.1 class I SAM-dependent methyltransferase -
M5I08_RS08985 (M5I08_08985) 1664866..1665123 + 258 WP_219067310.1 CopG family transcriptional regulator Antitoxin
M5I08_RS08990 (M5I08_08990) 1665120..1665548 + 429 WP_219067311.1 type II toxin-antitoxin system VapC family toxin Toxin
M5I08_RS08995 (M5I08_08995) 1665555..1666334 - 780 WP_219067312.1 DUF2127 domain-containing protein -
M5I08_RS09000 (M5I08_09000) 1666411..1666758 + 348 WP_219067313.1 GNAT family N-acetyltransferase -
M5I08_RS09005 (M5I08_09005) 1666906..1667457 + 552 WP_249763328.1 hypothetical protein -
M5I08_RS09010 (M5I08_09010) 1667516..1669612 - 2097 WP_219067368.1 manganese-exporting P-type ATPase CtpC -
M5I08_RS09015 (M5I08_09015) 1669644..1669922 - 279 WP_219067314.1 DUF1490 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-37)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15526.64 Da        Isoelectric Point: 4.8405

>T245127 WP_219067311.1 NZ_CP097320:1665120-1665548 [Candidatus Mycobacterium methanotrophicum]
MRLLDLNILIYAMDESSSRHQRARDWLDDTLSGSDTVAFAWQVLVGFVRLATRAAVFARPLTVDESFDVVDGWLAQPCVT
VVHPTDRHANVLRGLLIPLGAAGNLTSDAHLAALAIEHGAELCSTDVDFSRFSGVRWIDPLG

Download         Length: 429 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9516.88 Da        Isoelectric Point: 11.3519

>AT245127 WP_219067310.1 NZ_CP097320:1664866-1665123 [Candidatus Mycobacterium methanotrophicum]
MRTTVTLDPDVVAALQRVARQRGTSFKAVLNDAVRRGLGSEPTRRRYRTPSRDMGIRPEFDVDKAVALAAADEDAEIVRK
LAHRK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References