245126

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-YefM
Location 1256422..1256960 Replicon chromosome
Accession NZ_CP097320
Organism Candidatus Mycobacterium methanotrophicum isolate Sulfur Cave

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M5I08_RS06860 Protein ID WP_219066353.1
Coordinates 1256422..1256688 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M5I08_RS06865 Protein ID WP_219066352.1
Coordinates 1256685..1256960 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5I08_RS06830 (M5I08_06830) 1252063..1252335 + 273 Protein_1349 ATP-binding protein -
M5I08_RS06835 (M5I08_06835) 1252332..1252802 - 471 WP_219066356.1 transposase -
M5I08_RS06840 (M5I08_06840) 1252913..1253038 - 126 Protein_1351 ATP-binding protein -
M5I08_RS06845 (M5I08_06845) 1253037..1253315 + 279 Protein_1352 IS5/IS1182 family transposase -
M5I08_RS06850 (M5I08_06850) 1254258..1255853 + 1596 WP_219066355.1 Na+/H+ antiporter -
M5I08_RS06855 (M5I08_06855) 1256021..1256263 - 243 WP_219066354.1 hypothetical protein -
M5I08_RS06860 (M5I08_06860) 1256422..1256688 - 267 WP_219066353.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5I08_RS06865 (M5I08_06865) 1256685..1256960 - 276 WP_219066352.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M5I08_RS06870 (M5I08_06870) 1257196..1257792 - 597 WP_249763170.1 DUF6431 domain-containing protein -
M5I08_RS06875 (M5I08_06875) 1258011..1258846 + 836 Protein_1358 class I SAM-dependent methyltransferase -
M5I08_RS06880 (M5I08_06880) 1259278..1260291 - 1014 WP_219066351.1 low-specificity L-threonine aldolase -
M5I08_RS26140 1260359..1260700 - 342 WP_255564665.1 isochorismatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1252063..1252335 272


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10186.74 Da        Isoelectric Point: 11.2822

>T245126 WP_219066353.1 NZ_CP097320:c1256688-1256422 [Candidatus Mycobacterium methanotrophicum]
VSWTVGLASSARRDIDKLPPRVIPAVVEFIYGPLASDPRRIGKPLRENFHGHWSARRGDYRVLYMLDEHRQQIVIIRVGH
RSQVYRPG

Download         Length: 267 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10179.54 Da        Isoelectric Point: 5.5878

>AT245126 WP_219066352.1 NZ_CP097320:c1256960-1256685 [Candidatus Mycobacterium methanotrophicum]
MTTLPLTEAKAKLNELIDSAINTHERVTITRHGKPAAVLMSVEDLEALEETLYWQSQPGVHEDIAKAREQAEAGLLMTEG
EVRRRYGVGHR

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References