Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 564638..565638 | Replicon | chromosome |
| Accession | NZ_CP097320 | ||
| Organism | Candidatus Mycobacterium methanotrophicum isolate Sulfur Cave | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | M5I08_RS03050 | Protein ID | WP_219068325.1 |
| Coordinates | 565066..565638 (+) | Length | 191 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | - |
| Locus tag | M5I08_RS03045 | Protein ID | WP_219068326.1 |
| Coordinates | 564638..565069 (+) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M5I08_RS03030 (M5I08_03030) | 563287..563751 | - | 465 | Protein_595 | lytic transglycosylase domain-containing protein | - |
| M5I08_RS03035 (M5I08_03035) | 563808..564228 | + | 421 | Protein_596 | IS1380 family transposase | - |
| M5I08_RS03040 (M5I08_03040) | 564284..564496 | + | 213 | Protein_597 | ADP-ribosylglycohydrolase family protein | - |
| M5I08_RS03045 (M5I08_03045) | 564638..565069 | + | 432 | WP_219068326.1 | ParD-like family protein | Antitoxin |
| M5I08_RS03050 (M5I08_03050) | 565066..565638 | + | 573 | WP_219068325.1 | zeta toxin family protein | Toxin |
| M5I08_RS03055 (M5I08_03055) | 565865..566122 | + | 258 | WP_219068324.1 | hypothetical protein | - |
| M5I08_RS03060 (M5I08_03060) | 566115..566588 | + | 474 | WP_219068323.1 | hypothetical protein | - |
| M5I08_RS03065 (M5I08_03065) | 566591..566767 | + | 177 | Protein_602 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| M5I08_RS03070 (M5I08_03070) | 566841..567257 | - | 417 | WP_219068322.1 | PIN domain-containing protein | - |
| M5I08_RS03075 (M5I08_03075) | 567260..567502 | - | 243 | WP_219068321.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| M5I08_RS03080 (M5I08_03080) | 567573..568028 | - | 456 | WP_219068320.1 | nitroreductase family protein | - |
| M5I08_RS03085 (M5I08_03085) | 568566..569792 | + | 1227 | WP_249763285.1 | IS110 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 564028..564249 | 221 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 191 a.a. Molecular weight: 20732.51 Da Isoelectric Point: 6.8464
>T245124 WP_219068325.1 NZ_CP097320:565066-565638 [Candidatus Mycobacterium methanotrophicum]
MKRLDLVVGPNGAGKSTFVELTLAPLLPGSAFVNADEIARQRWPDDPASHAYQAARVAAETRARLIEVGASFIAETVFSH
PSKLELIDTAHAGDYTIVLHVMLIPEELAVERVRHRVSAGGHHVPEDKIRERYQRLWGLVAAATSRCDSTTVYDNSALQG
PRIIAQMNDGFLVGSSAWPAWTPDALRSGR
MKRLDLVVGPNGAGKSTFVELTLAPLLPGSAFVNADEIARQRWPDDPASHAYQAARVAAETRARLIEVGASFIAETVFSH
PSKLELIDTAHAGDYTIVLHVMLIPEELAVERVRHRVSAGGHHVPEDKIRERYQRLWGLVAAATSRCDSTTVYDNSALQG
PRIIAQMNDGFLVGSSAWPAWTPDALRSGR
Download Length: 573 bp
Antitoxin
Download Length: 144 a.a. Molecular weight: 15389.18 Da Isoelectric Point: 10.5347
>AT245124 WP_219068326.1 NZ_CP097320:564638-565069 [Candidatus Mycobacterium methanotrophicum]
MANTADRVTRVAADLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQQTAARRRVEAALTGDLELRELSVEEGAVFNAEI
AAAVEERLAGSNYGTLLAERGITTVALDENGDIVEHRPDGSSVVLATKRRAPRRRKARAAPTR
MANTADRVTRVAADLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQQTAARRRVEAALTGDLELRELSVEEGAVFNAEI
AAAVEERLAGSNYGTLLAERGITTVALDENGDIVEHRPDGSSVVLATKRRAPRRRKARAAPTR
Download Length: 432 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|