245123

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 553793..554334 Replicon chromosome
Accession NZ_CP097320
Organism Candidatus Mycobacterium methanotrophicum isolate Sulfur Cave

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M5I08_RS02995 Protein ID WP_219068331.1
Coordinates 553793..554119 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag M5I08_RS03000 Protein ID WP_219068330.1
Coordinates 554116..554334 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5I08_RS02950 (M5I08_02950) 549063..549497 - 435 WP_219068336.1 type II toxin-antitoxin system VapC family toxin -
M5I08_RS02955 (M5I08_02955) 549494..549790 - 297 WP_219068335.1 toxin-antitoxin system HicB family antitoxin -
M5I08_RS02960 (M5I08_02960) 549787..550065 - 279 WP_249763089.1 hypothetical protein -
M5I08_RS02965 (M5I08_02965) 550043..550501 + 459 WP_249763090.1 AAA family ATPase -
M5I08_RS02970 (M5I08_02970) 550443..551954 + 1512 WP_249763091.1 hypothetical protein -
M5I08_RS02975 (M5I08_02975) 551951..552289 + 339 WP_219068334.1 hypothetical protein -
M5I08_RS02980 (M5I08_02980) 552290..552952 - 663 WP_219068333.1 NUDIX domain-containing protein -
M5I08_RS02985 (M5I08_02985) 553028..553321 + 294 WP_249763092.1 ADP-ribosylglycohydrolase family protein -
M5I08_RS02990 (M5I08_02990) 553215..553763 + 549 WP_249763468.1 hypothetical protein -
M5I08_RS02995 (M5I08_02995) 553793..554119 - 327 WP_219068331.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M5I08_RS03000 (M5I08_03000) 554116..554334 - 219 WP_219068330.1 antitoxin MazE family protein Antitoxin
M5I08_RS03005 (M5I08_03005) 554382..554537 - 156 WP_219068329.1 hypothetical protein -
M5I08_RS03010 (M5I08_03010) 554917..558297 + 3381 WP_219068328.1 TM0106 family RecB-like putative nuclease -
M5I08_RS03015 (M5I08_03015) 558377..558535 - 159 WP_249763093.1 hypothetical protein -
M5I08_RS03020 (M5I08_03020) 558793..559284 + 492 Protein_593 FKBP-type peptidyl-prolyl cis-trans isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-102)

Antitoxin

Antitoxin MazE-like

(7-68)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11553.40 Da        Isoelectric Point: 7.8314

>T245123 WP_219068331.1 NZ_CP097320:c554119-553793 [Candidatus Mycobacterium methanotrophicum]
VRRGELWTAAGGKHYAGKPRPVLIVQDDRFDATSSITVCPLTSDPTEIPLLRVPLDPDDSNCLDAPSSIMIDKITTMARS
KLGARIGKVSDAGMLALSRSLVVFLGFA

Download         Length: 327 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8114.98 Da        Isoelectric Point: 6.8800

>AT245123 WP_219068330.1 NZ_CP097320:c554334-554116 [Candidatus Mycobacterium methanotrophicum]
MTERRVRHRVAAHRERLRRQGLRPVQIWVPDVRAPGFAAEAHRQSALAAASPHEADDQAFVDAISSFGDDEE

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References