245122

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 523757..524349 Replicon chromosome
Accession NZ_CP097320
Organism Candidatus Mycobacterium methanotrophicum isolate Sulfur Cave

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5I08_RS02840 Protein ID WP_219068354.1
Coordinates 523757..524155 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M5I08_RS02845 Protein ID WP_219068353.1
Coordinates 524152..524349 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5I08_RS02820 (M5I08_02820) 519471..520055 - 585 WP_219068357.1 hypothetical protein -
M5I08_RS02825 (M5I08_02825) 520709..520858 + 150 WP_219068356.1 helix-turn-helix domain-containing protein -
M5I08_RS02830 (M5I08_02830) 520822..521943 - 1122 WP_219068355.1 Tn3 family transposase -
M5I08_RS02835 (M5I08_02835) 521900..523288 - 1389 WP_219068363.1 serine hydrolase domain-containing protein -
M5I08_RS02840 (M5I08_02840) 523757..524155 - 399 WP_219068354.1 PIN domain nuclease Toxin
M5I08_RS02845 (M5I08_02845) 524152..524349 - 198 WP_219068353.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M5I08_RS02850 (M5I08_02850) 524474..524635 + 162 WP_249763085.1 hypothetical protein -
M5I08_RS02855 (M5I08_02855) 524714..525628 + 915 WP_249763086.1 serine hydrolase domain-containing protein -
M5I08_RS02860 (M5I08_02860) 525615..527336 - 1722 WP_249763087.1 N-acetylmuramic acid 6-phosphate etherase -
M5I08_RS02865 (M5I08_02865) 528009..528422 + 414 Protein_562 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14654.02 Da        Isoelectric Point: 5.6343

>T245122 WP_219068354.1 NZ_CP097320:c524155-523757 [Candidatus Mycobacterium methanotrophicum]
VIVVDTSVWIDVLNDNPTPQAQRCVQLLESGEPIALTDVILTEVLQGLRSDREAALVERHLRAFPILRLEGLDDFVLAAK
LYRMARRAGVTIRKTLDCLIAAPCVHTGAPLLHADQDFDRLATCTPLRIWSS

Download         Length: 399 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7562.61 Da        Isoelectric Point: 11.1986

>AT245122 WP_219068353.1 NZ_CP097320:c524349-524152 [Candidatus Mycobacterium methanotrophicum]
MRTNIDIDDDVLREAQRLLGTRTKRDTVNLALRELVARHRQIGVLELRGKVHWDGELAESRRGRS

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References