245121

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 499251..499777 Replicon chromosome
Accession NZ_CP097320
Organism Candidatus Mycobacterium methanotrophicum isolate Sulfur Cave

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag M5I08_RS02670 Protein ID WP_219069889.1
Coordinates 499475..499777 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID -
Locus tag M5I08_RS02665 Protein ID WP_219069891.1
Coordinates 499251..499478 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5I08_RS02635 (M5I08_02635) 495383..496270 + 888 WP_249763074.1 tyrosine-type recombinase/integrase -
M5I08_RS02645 (M5I08_02645) 496558..497184 - 627 WP_249763075.1 hypothetical protein -
M5I08_RS02650 (M5I08_02650) 497545..498531 - 987 WP_219069897.1 alpha/beta hydrolase -
M5I08_RS02655 (M5I08_02655) 498604..498750 - 147 WP_219069895.1 hypothetical protein -
M5I08_RS02660 (M5I08_02660) 498747..498881 - 135 WP_219069893.1 chorismate mutase -
M5I08_RS02665 (M5I08_02665) 499251..499478 + 228 WP_219069891.1 ribbon-helix-helix protein, CopG family Antitoxin
M5I08_RS02670 (M5I08_02670) 499475..499777 + 303 WP_219069889.1 toxin Toxin
M5I08_RS02675 (M5I08_02675) 500164..500346 + 183 WP_219069887.1 hypothetical protein -
M5I08_RS02680 (M5I08_02680) 500334..500687 + 354 WP_219069885.1 ferredoxin family protein -
M5I08_RS02685 (M5I08_02685) 500765..501355 + 591 WP_249763076.1 transcriptional regulator -
M5I08_RS02690 (M5I08_02690) 501352..501552 + 201 Protein_527 hypothetical protein -
M5I08_RS02695 (M5I08_02695) 501984..502277 + 294 WP_219069883.1 hypothetical protein -
M5I08_RS02700 (M5I08_02700) 502556..502816 + 261 Protein_529 IS200/IS605 family transposase -
M5I08_RS02705 (M5I08_02705) 502906..503832 - 927 WP_219069909.1 questin oxidase family protein -
M5I08_RS02710 (M5I08_02710) 503904..504230 - 327 WP_219069879.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10385.12 Da        Isoelectric Point: 4.1313

>T245121 WP_219069889.1 NZ_CP097320:499475-499777 [Candidatus Mycobacterium methanotrophicum]
VITPGDITPRRDTDQELYVIVLSNAIHLAAATGRVITCPFIPGEIPSGTMAMIVTVQQPKGVVLPELIQWLPVAALDEPI
GNIGGAALADTTVTVTALVS

Download         Length: 303 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8198.23 Da        Isoelectric Point: 5.6131

>AT245121 WP_219069891.1 NZ_CP097320:499251-499478 [Candidatus Mycobacterium methanotrophicum]
MAKDKVSVTIDQAVLAAADADAQAAGLNRSEMIERALHNEHLRISLQNYITRTVPTLDIDAYAEKVYQSNRAAGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References