245119

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 3263558..3264186 Replicon chromosome
Accession NZ_CP097315
Organism Leptospira interrogans strain N 116

Toxin (Protein)


Gene name vapC Uniprot ID Q8F7E4
Locus tag MY415_RS13720 Protein ID WP_000281042.1
Coordinates 3263788..3264186 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q8F7E3
Locus tag MY415_RS13715 Protein ID WP_001192482.1
Coordinates 3263558..3263788 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY415_RS20050 3259380..3259514 + 135 WP_002188572.1 hypothetical protein -
MY415_RS13685 (MY415_13685) 3259551..3259910 + 360 WP_002188605.1 tyrosine-type recombinase/integrase -
MY415_RS13690 (MY415_13690) 3259942..3260964 + 1023 WP_000288518.1 hypothetical protein -
MY415_RS13695 (MY415_13695) 3261019..3261546 + 528 WP_002188620.1 hypothetical protein -
MY415_RS13700 (MY415_13700) 3261825..3262160 + 336 WP_000669388.1 type II toxin-antitoxin system RelE/ParE family toxin -
MY415_RS13705 (MY415_13705) 3262157..3262456 + 300 WP_000769809.1 helix-turn-helix transcriptional regulator -
MY415_RS13710 (MY415_13710) 3262577..3263206 + 630 WP_000639168.1 hypothetical protein -
MY415_RS13715 (MY415_13715) 3263558..3263788 + 231 WP_001192482.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MY415_RS13720 (MY415_13720) 3263788..3264186 + 399 WP_000281042.1 type II toxin-antitoxin system VapC family toxin Toxin
MY415_RS13725 (MY415_13725) 3264284..3264583 + 300 Protein_2728 hypothetical protein -
MY415_RS13730 (MY415_13730) 3264605..3264832 + 228 WP_000130601.1 hypothetical protein -
MY415_RS13735 (MY415_13735) 3264974..3266050 + 1077 WP_001170569.1 hypothetical protein -
MY415_RS13740 (MY415_13740) 3266051..3266509 + 459 WP_001239006.1 GNAT family N-acetyltransferase -
MY415_RS13745 (MY415_13745) 3266726..3267588 - 863 Protein_2732 hypothetical protein -
MY415_RS13750 (MY415_13750) 3268099..3268866 - 768 WP_000636953.1 DUF1554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15139.76 Da        Isoelectric Point: 9.6893

>T245119 WP_000281042.1 NZ_CP097315:3263788-3264186 [Leptospira interrogans]
MYLLDTNICIFLIKKKNATLLENLKKKLNKDLFVSSLTVAELEFGIQKSEFKEKNKVALIEFLTIFNILSFSDKDAESYG
IIRADLERKGNVIGSIDMLLAAQAIANNYIFVTNNTKEFKRIKALKIENWTQ

Download         Length: 399 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8771.05 Da        Isoelectric Point: 8.6588

>AT245119 WP_001192482.1 NZ_CP097315:3263558-3263788 [Leptospira interrogans]
MQTAKLFINGRSQAVRLPKEFQFTGDDVLIQKVGEAVILVPKNKAWNVFLEGLNGFSDDFFKEEREQPKSDKREKL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6HAN6

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6HAF7

References