245118

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 1023053..1023629 Replicon chromosome
Accession NZ_CP097315
Organism Leptospira interrogans strain N 116

Toxin (Protein)


Gene name chpK Uniprot ID Q93MT8
Locus tag MY415_RS04475 Protein ID WP_000617906.1
Coordinates 1023288..1023629 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID Q93MT9
Locus tag MY415_RS04470 Protein ID WP_000844758.1
Coordinates 1023053..1023301 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY415_RS04455 (MY415_04455) 1018704..1020686 + 1983 WP_000836894.1 GAF domain-containing protein -
MY415_RS04460 (MY415_04460) 1021328..1021786 - 459 WP_000453267.1 hypothetical protein -
MY415_RS04465 (MY415_04465) 1021940..1022236 + 297 WP_000477061.1 helix-turn-helix transcriptional regulator -
MY415_RS04470 (MY415_04470) 1023053..1023301 + 249 WP_000844758.1 ribbon-helix-helix domain-containing protein Antitoxin
MY415_RS04475 (MY415_04475) 1023288..1023629 + 342 WP_000617906.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MY415_RS04480 (MY415_04480) 1024724..1025236 + 513 WP_000079224.1 VOC family protein -
MY415_RS04485 (MY415_04485) 1025920..1026513 + 594 WP_001226990.1 dihydrofolate reductase family protein -
MY415_RS04490 (MY415_04490) 1026585..1027472 + 888 WP_002188401.1 hypothetical protein -
MY415_RS04495 (MY415_04495) 1027590..1028336 + 747 WP_000617027.1 GNAT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12372.25 Da        Isoelectric Point: 6.3272

>T245118 WP_000617906.1 NZ_CP097315:1023288-1023629 [Leptospira interrogans]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD

Download         Length: 342 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9380.77 Da        Isoelectric Point: 10.3815

>AT245118 WP_000844758.1 NZ_CP097315:1023053-1023301 [Leptospira interrogans]
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETRNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4MS74

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6HD92

References