Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 2850213..2850852 Replicon chromosome
Accession NZ_CP097314
Organism Rummeliibacillus sp. G93

Toxin (Protein)


Gene name pemK Uniprot ID A0A143HEK3
Locus tag M2M59_RS14360 Protein ID WP_066790273.1
Coordinates 2850213..2850563 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag M2M59_RS14365 Protein ID WP_236717644.1
Coordinates 2850568..2850852 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2M59_RS14335 (M2M59_14335) 2845501..2847654 - 2154 WP_147197145.1 Tex family protein -
M2M59_RS14340 (M2M59_14340) 2847758..2848537 - 780 WP_066790265.1 RNA polymerase sigma factor SigB -
M2M59_RS14345 (M2M59_14345) 2848515..2848985 - 471 WP_066790267.1 anti-sigma B factor RsbW -
M2M59_RS14350 (M2M59_14350) 2848972..2849313 - 342 WP_147197143.1 STAS domain-containing protein -
M2M59_RS14355 (M2M59_14355) 2849503..2849916 - 414 WP_147197141.1 anti-sigma regulatory factor -
M2M59_RS14360 (M2M59_14360) 2850213..2850563 - 351 WP_066790273.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2M59_RS14365 (M2M59_14365) 2850568..2850852 - 285 WP_236717644.1 transcriptional regulator Antitoxin
M2M59_RS14370 (M2M59_14370) 2851057..2852181 - 1125 WP_249774936.1 alanine racemase -
M2M59_RS14375 (M2M59_14375) 2852356..2853627 - 1272 WP_249774937.1 outer membrane lipoprotein carrier protein LolA -
M2M59_RS14380 (M2M59_14380) 2853681..2854034 - 354 WP_066790282.1 holo-ACP synthase -
M2M59_RS14385 (M2M59_14385) 2854103..2854711 + 609 WP_249774938.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12818.94 Da        Isoelectric Point: 7.0151

>T245117 WP_066790273.1 NZ_CP097314:c2850563-2850213 [Rummeliibacillus sp. G93]
MNVKRGDVFFADLSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDGPLMVKVEEALEISLGLLKF

Download         Length: 351 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10837.50 Da        Isoelectric Point: 6.6357

>AT245117 WP_236717644.1 NZ_CP097314:c2850852-2850568 [Rummeliibacillus sp. G93]
VNHKGLENVLIQMPERLVSESIEQAYRQIVLKDANDLVYIPTKRSIHTKQKNHMREAMVKGYVEMSQINLSICSECLHVE
YEAEHMVERLVSGG

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143HEK3

Antitoxin

Source ID Structure

References