Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1806832..1807360 Replicon chromosome
Accession NZ_CP097294
Organism Vibrio sp. J383

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag M4S28_RS24380 Protein ID WP_005377002.1
Coordinates 1807070..1807360 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID K5UYY9
Locus tag M4S28_RS24375 Protein ID WP_004730320.1
Coordinates 1806832..1807080 (+) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4S28_RS24345 (M4S28_24345) 1802622..1803521 - 900 WP_249633101.1 LysR substrate-binding domain-containing protein -
M4S28_RS24350 (M4S28_24350) 1803661..1804509 + 849 WP_249633102.1 DMT family transporter -
M4S28_RS24355 (M4S28_24355) 1804750..1805214 - 465 WP_249633103.1 Sbal_3080 family lipoprotein -
M4S28_RS24360 (M4S28_24360) 1805411..1805809 + 399 WP_249633104.1 hypothetical protein -
M4S28_RS24365 (M4S28_24365) 1805867..1806637 - 771 WP_249633105.1 chromosome partitioning protein ParA -
M4S28_RS24370 (M4S28_24370) 1806689..1806757 - 69 WP_077672877.1 DUF3265 domain-containing protein -
M4S28_RS24375 (M4S28_24375) 1806832..1807080 + 249 WP_004730320.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M4S28_RS24380 (M4S28_24380) 1807070..1807360 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4S28_RS24385 (M4S28_24385) 1807379..1807780 - 402 WP_061025733.1 hypothetical protein -
M4S28_RS24390 (M4S28_24390) 1807800..1807928 - 129 WP_249633769.1 DUF3265 domain-containing protein -
M4S28_RS24400 (M4S28_24400) 1809642..1810103 - 462 WP_249633107.1 hypothetical protein -
M4S28_RS24405 (M4S28_24405) 1810118..1810393 - 276 WP_249633108.1 hypothetical protein -
M4S28_RS24410 (M4S28_24410) 1810538..1810897 - 360 WP_249633109.1 Ypar14, super integron cassette -
M4S28_RS24415 (M4S28_24415) 1811183..1812274 - 1092 WP_249633110.1 transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1790870..1817261 26391


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-83)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T245115 WP_005377002.1 NZ_CP097294:1807070-1807360 [Vibrio sp. J383]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp


Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9109.39 Da        Isoelectric Point: 3.9610

>AT245115 WP_004730320.1 NZ_CP097294:1806832-1807080 [Vibrio sp. J383]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLTIAKERESEESISVNID
DL

Download         Length: 249 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A347UR03


Antitoxin

Source ID Structure
AlphaFold DB A0A0L1LA33

References