Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 3798052..3798599 Replicon chromosome
Accession NZ_CP097291
Organism Providencia sp. PROV188

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag M5X66_RS17525 Protein ID WP_270103755.1
Coordinates 3798393..3798599 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M5X66_RS17520 Protein ID WP_108479168.1
Coordinates 3798052..3798339 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5X66_RS17495 (M5X66_17495) 3793099..3794076 - 978 WP_036950827.1 6-phosphofructokinase -
M5X66_RS17500 (M5X66_17500) 3794487..3795431 - 945 WP_036950825.1 phosphatidate cytidylyltransferase -
M5X66_RS17505 (M5X66_17505) 3795428..3796069 - 642 WP_036950823.1 lysophospholipid acyltransferase family protein -
M5X66_RS17510 (M5X66_17510) 3796306..3797061 - 756 WP_036950820.1 M48 family metallopeptidase -
M5X66_RS17515 (M5X66_17515) 3797316..3797897 - 582 WP_036950818.1 HutD family protein -
M5X66_RS17520 (M5X66_17520) 3798052..3798339 - 288 WP_108479168.1 putative addiction module antidote protein Antitoxin
M5X66_RS17525 (M5X66_17525) 3798393..3798599 - 207 WP_270103755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5X66_RS17530 (M5X66_17530) 3798887..3799447 - 561 WP_036950811.1 Spy/CpxP family protein refolding chaperone -
M5X66_RS17535 (M5X66_17535) 3799599..3800297 + 699 WP_006660535.1 envelope stress response regulator transcription factor CpxR -
M5X66_RS17540 (M5X66_17540) 3800294..3801664 + 1371 WP_036950809.1 envelope stress sensor histidine kinase CpxA -
M5X66_RS17545 (M5X66_17545) 3802537..3803496 + 960 WP_270103756.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-68)

Antitoxin

Uncharacterized protein HI1420

(4-91)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7742.97 Da        Isoelectric Point: 10.4688

>T245111 WP_270103755.1 NZ_CP097291:c3798599-3798393 [Providencia sp. PROV188]
MHDLKDIRAKTKIQIRIRRLKQGNFGDVESIGDGFSELKIHEGKGYRVYLRKIDNTIVLLISGGDKST

Download         Length: 207 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10574.21 Da        Isoelectric Point: 5.1489

>AT245111 WP_108479168.1 NZ_CP097291:c3798339-3798052 [Providencia sp. PROV188]
MNIKIKEYDIAEHLTNEEEIQLYLNEILEEGDTALILAALGDIARARNMTQLAKEVGMSREGLYKALSGEGNPAFTTILK
IVHSLGLKLQFKSAR

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References