Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3622149..3622791 Replicon chromosome
Accession NZ_CP097291
Organism Providencia sp. PROV188

Toxin (Protein)


Gene name vapC Uniprot ID A0A6L6F8F2
Locus tag M5X66_RS16630 Protein ID WP_036948921.1
Coordinates 3622149..3622556 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4R3NJB3
Locus tag M5X66_RS16635 Protein ID WP_036948919.1
Coordinates 3622549..3622791 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5X66_RS16600 (M5X66_16600) 3617721..3619049 - 1329 WP_036948929.1 N-acetylmuramoyl-L-alanine amidase AmiB -
M5X66_RS16605 (M5X66_16605) 3619064..3619528 - 465 WP_036948926.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
M5X66_RS16610 (M5X66_16610) 3619743..3620900 + 1158 WP_108478804.1 tRNA epoxyqueuosine(34) reductase QueG -
M5X66_RS16630 (M5X66_16630) 3622149..3622556 - 408 WP_036948921.1 tRNA(fMet)-specific endonuclease VapC Toxin
M5X66_RS16635 (M5X66_16635) 3622549..3622791 - 243 WP_036948919.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M5X66_RS16640 (M5X66_16640) 3622875..3623417 - 543 WP_036948917.1 oligoribonuclease -
M5X66_RS16645 (M5X66_16645) 3623555..3624607 + 1053 WP_036948915.1 small ribosomal subunit biogenesis GTPase RsgA -
M5X66_RS16650 (M5X66_16650) 3624741..3625634 + 894 WP_036948913.1 archaetidylserine decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15161.42 Da        Isoelectric Point: 7.3226

>T245110 WP_036948921.1 NZ_CP097291:c3622556-3622149 [Providencia sp. PROV188]
MIKYLLDTNIVIFTIKRRPAALLPKFNQHADQLAISTITLAELVFGAEKSMNPERNLAVVNDFVSRLCVLPYDEAAACHY
GDIRANLEKQGKKIGENDLHIAAHARSKGLIVVTNNTREFERVDGLRLEDWVNSS

Download         Length: 408 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9330.58 Da        Isoelectric Point: 5.0774

>AT245110 WP_036948919.1 NZ_CP097291:c3622791-3622549 [Providencia sp. PROV188]
MILHSKVFMSNRTQNVRLPAELRFPDDVKEVTVRMKGKERIITPLQNTWDSFFLTETSATDDFLVSRAEQVPTPRESFDD

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L6F8F2

Antitoxin

Source ID Structure
AlphaFold DB A0A4R3NJB3

References