Detailed information of TA system TA024511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3718421..3720119
• Replicon: chromosome
• Accession: NC_013716
• Organism: Citrobacter rodentium ICC168

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: D2TQV0
• Locus tag: ROD_RS17365
• Protein ID: WP_012907576.1
• Coordinates: 3718421..3719350 (-)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: ROD_RS17370
• Protein ID: WP_024132931.1
• Coordinates: 3719337..3720119 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ROD_RS17345	3714233..3714961	-	729	WP_012907571.1	winged helix-turn-helix domain-containing protein	-
ROD_RS26620	3715133..3715513	+	381	WP_012907572.1	hypothetical protein	-
ROD_RS17355	3715990..3716442	+	453	WP_012907574.1	glyoxalase/bleomycin resistance/dioxygenase family protein	-
ROD_RS17360	3716611..3717825	+	1215	WP_024132930.1	PD-(D/E)XK nuclease family protein	-
ROD_RS17365	3718421..3719350	-	930	WP_012907576.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ROD_RS17370	3719337..3720119	-	783	WP_024132931.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
ROD_RS28340	3720436..3720762	+	327	WP_148222105.1	hypothetical protein	-
ROD_RS28675	3721130..3721399	+	270	WP_162467723.1	hypothetical protein	-
ROD_RS17380	3721857..3722150	+	294	WP_012907581.1	DUF1778 domain-containing protein	-
ROD_RS17385	3722147..3722488	+	342	Protein_3439	GNAT family N-acetyltransferase	-
ROD_RS17390	3722543..3723220	+	678	WP_012904569.1	IS66 family insertion sequence hypothetical protein	-
ROD_RS17395	3723220..3723567	+	348	WP_012904570.1	IS66 family insertion sequence element accessory protein TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3713180..3714103	923

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-268)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (96-247)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35000.57 Da
• Isoelectric Point: 6.9537

>T24511 WP_012907576.1 NC_013716:c3719350-3718421 [Citrobacter rodentium ICC168]
MDLRDIYARQVRLLMTALPLVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLVAIHDALMRITKSLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPTEMPVCEQVEMEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLVGHPRPIAELLAPNWDTTQIATLYAQEFSGMTQQETSLDSLLSVTTLLPQAL
KSHLTGKDRQFLLTYKQNTPDWSLYRYPEIQHLPAIRWKLRNLEVLNDKNPAKYAAAVSKLEGVLKQYF

Nucleotide

• Length: 930 bp

>T24511 NC_013716:c3719350-3718421 [Citrobacter rodentium ICC168]
ATGGATCTGCGTGATATTTATGCCCGACAGGTCAGGCTATTAATGACTGCTCTGCCGCTTGTGGCAAAGGAGTCCTGCTT
CGCGCTGAAAGGCGGCACGGCAATCAATTTGTTTGTACAGGATTTCCCTCGCCTGTCGGTGGATATCGATCTTGCTTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGTTGCCATCCATGACGCCCTGATGCGTATTACTAAATCGCTGAATGGCAGG
CCAGGGATCACGGCGATCCGGCAGGAGAATAAAGCGGATGAAAAGCGCATCATCGTTAACACCGCCGATGCGAAGATAAA
GATTGAGGTTAGTCCGGTCTGGCGTGGACTACTGTTGCCACCAACAGAAATGCCAGTATGTGAACAGGTGGAAATGGAAT
ATGGCTTCACCACCATGAATGTTGTCTCGCTGGCGGATCTTTACGGCGGTAAAATCTGCGCTGCGCTTGACCGCCAGCAT
CCACGCGATCTGTTTGACGTGCTGAATATGCTGGAGAAACCGGGTCTGACACGTGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGTAGGCCATCCCCGCCCCATTGCTGAACTGCTGGCACCAAACTGGGACACGACCCAGATCGCCACGCTGTACGCAC
AGGAATTTTCAGGGATGACACAACAGGAAACTTCGCTGGACTCTCTTTTGTCAGTCACAACCTTGCTACCGCAGGCGCTG
AAATCGCACCTTACGGGCAAAGATCGCCAGTTCCTGCTCACCTATAAGCAAAATACTCCTGACTGGTCGCTGTATCGCTA
TCCTGAAATTCAACACCTACCGGCTATTCGCTGGAAGTTGCGTAACCTGGAGGTGCTGAATGATAAGAATCCGGCCAAGT
ATGCAGCGGCAGTGAGTAAGCTGGAGGGGGTTCTGAAGCAGTATTTTTAG

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29342.64 Da
• Isoelectric Point: 8.7200

>AT24511 WP_024132931.1 NC_013716:c3720119-3719337 [Citrobacter rodentium ICC168]
MANYLNWLMQNTLPGQVLLQSWLTRNGIDRKLSYLYVQNDWLRRIAHGVYCRTGREPNWVDAVYCLQTQWGKKVRVAGLT
SLALQGHAHYTEPGRQQIWLALPAYVKLPGWFTAFEQSATFVTLYTSGLTVDTTLFATKLNIGDRQLMGSVPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQTLLCASHSVKTNRVMLYLARRNEHPYFQYLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT24511 NC_013716:c3720119-3719337 [Citrobacter rodentium ICC168]
TTGGCAAACTATCTAAACTGGCTGATGCAGAACACCCTCCCCGGTCAGGTTTTGCTCCAGTCATGGCTCACCCGCAATGG
CATAGATCGTAAGCTCTCTTACCTCTATGTGCAGAATGACTGGCTCAGGCGGATCGCGCACGGCGTATATTGTCGGACGG
GCCGTGAGCCGAACTGGGTGGACGCAGTTTACTGTCTGCAAACGCAGTGGGGGAAAAAAGTTCGCGTGGCGGGGCTGACC
AGCCTTGCGCTACAGGGCCACGCTCACTATACCGAACCGGGTAGACAACAAATCTGGCTTGCACTACCGGCTTACGTCAA
ACTGCCGGGATGGTTCACCGCCTTTGAGCAATCCGCGACGTTTGTCACGCTGTATACCTCTGGTCTCACCGTCGATACAA
CACTATTCGCAACAAAACTAAATATCGGCGACCGGCAGTTAATGGGCAGTGTCCCGGAACTGGCCGCATATGAGATAGCC
TGCGGCGTTCCTTCGTTGATCTCCTTCGAACATGCCGACGCTCTGTTTCAGGGGATGAATCTTCTCAGCCCGCGTAAATT
ACAGACACTGCTCTGCGCCAGTCATTCGGTTAAAACCAACCGGGTGATGCTTTACCTTGCCCGACGCAATGAGCATCCTT
ACTTTCAGTATCTCGATCAAAGCGGTATAGAAACAGGCACGGGAAAACGGCAAATTGTTCCCGGCGGCTGGCTGGAACCG
GATTATCAAATCACCGTTCCCCGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Structures

Toxin

• AlphaFold DB: D2TQV0