Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 810557..811201 Replicon chromosome
Accession NZ_CP097291
Organism Providencia sp. PROV188

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag M5X66_RS03545 Protein ID WP_004905417.1
Coordinates 810557..810760 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag M5X66_RS03550 Protein ID WP_270103878.1
Coordinates 810833..811201 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5X66_RS03525 (M5X66_03525) 806405..808189 + 1785 WP_036953934.1 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein -
M5X66_RS03530 (M5X66_03530) 808347..809213 - 867 WP_036953936.1 acyl-CoA thioesterase II -
M5X66_RS03535 (M5X66_03535) 809452..809910 + 459 WP_036953939.1 YbaY family lipoprotein -
M5X66_RS03545 (M5X66_03545) 810557..810760 - 204 WP_004905417.1 HHA domain-containing protein Toxin
M5X66_RS03550 (M5X66_03550) 810833..811201 - 369 WP_270103878.1 Hha toxicity modulator TomB Antitoxin
M5X66_RS03555 (M5X66_03555) 811729..813108 - 1380 WP_108479260.1 murein transglycosylase D -
M5X66_RS03560 (M5X66_03560) 813191..813943 - 753 WP_270103879.1 hydroxyacylglutathione hydrolase -
M5X66_RS03565 (M5X66_03565) 813978..814703 + 726 WP_036953950.1 methyltransferase domain-containing protein -
M5X66_RS03570 (M5X66_03570) 814716..815186 - 471 WP_036953952.1 ribonuclease HI -
M5X66_RS03575 (M5X66_03575) 815241..816002 + 762 WP_036953954.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T245106 WP_004905417.1 NZ_CP097291:c810760-810557 [Providencia sp. PROV188]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14117.98 Da        Isoelectric Point: 4.4687

>AT245106 WP_270103878.1 NZ_CP097291:c811201-810833 [Providencia sp. PROV188]
MDEYSPKKHDIAELKYLCNSLNRDAISSLQKTNTHWVNDLSSAQSISLNELVEHIAAFVWRFKIKYPKENLVISLVEEYL
DETYNLFGSPVITFSEIIDWESMNQNLVTVLDDDLKCLTSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure

References