Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 5579606..5580288 Replicon chromosome
Accession NZ_CP097289
Organism Streptomyces durmitorensis strain MS405

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M4V62_RS25050 Protein ID WP_249589471.1
Coordinates 5579884..5580288 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M4V62_RS25045 Protein ID WP_249589470.1
Coordinates 5579606..5579887 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4V62_RS25025 (M4V62_25025) 5575600..5576166 + 567 WP_249589467.1 hypothetical protein -
M4V62_RS25030 (M4V62_25030) 5576163..5577728 + 1566 WP_283779167.1 serine/threonine-protein kinase -
M4V62_RS25035 (M4V62_25035) 5577861..5578526 + 666 WP_249589468.1 SurA N-terminal domain-containing protein -
M4V62_RS25040 (M4V62_25040) 5578585..5579574 + 990 WP_249589469.1 nucleoside triphosphate pyrophosphohydrolase -
M4V62_RS25045 (M4V62_25045) 5579606..5579887 + 282 WP_249589470.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M4V62_RS25050 (M4V62_25050) 5579884..5580288 + 405 WP_249589471.1 type II toxin-antitoxin system VapC family toxin Toxin
M4V62_RS25055 (M4V62_25055) 5580335..5581702 + 1368 WP_249589472.1 cytochrome P450 -
M4V62_RS25060 (M4V62_25060) 5581839..5582831 + 993 WP_249589473.1 transglycosylase family protein -
M4V62_RS25065 (M4V62_25065) 5583208..5583918 + 711 WP_249589474.1 transglycosylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-46)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14797.92 Da        Isoelectric Point: 5.7514

>T245105 WP_249589471.1 NZ_CP097289:5579884-5580288 [Streptomyces durmitorensis]
VIYLDSCVLLKFIKPEKETEALRAWRAGLPDGTELLGSELARLEITRTLYRAGVDHQRVPFFVGQAVRGVYLADVTTTVM
ARAAAYRTQRLGTLDAIHLASADPFRQDITEFVTYGQELARAAEELGFPVSSPA

Download         Length: 405 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10208.62 Da        Isoelectric Point: 4.6936

>AT245105 WP_249589470.1 NZ_CP097289:5579606-5579887 [Streptomyces durmitorensis]
METIGLRELNQNPSKAVARVRAGASILVTDRGKPVLRMVPETEAPGTLQRLLESGDVTAPAEQGMPEVFTDLAPELGSLS
DVLLEERDRERRR

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References