Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1273173..1274196 Replicon chromosome
Accession NZ_CP097289
Organism Streptomyces durmitorensis strain MS405

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag M4V62_RS06040 Protein ID WP_249592709.1
Coordinates 1273774..1274196 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag M4V62_RS06035 Protein ID WP_249586178.1
Coordinates 1273173..1273634 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4V62_RS06030 (M4V62_06030) 1269502..1269899 - 398 Protein_1202 hypothetical protein -
M4V62_RS06035 (M4V62_06035) 1273173..1273634 + 462 WP_249586178.1 helix-turn-helix domain-containing protein Antitoxin
M4V62_RS06040 (M4V62_06040) 1273774..1274196 + 423 WP_249592709.1 PIN domain-containing protein Toxin
M4V62_RS06045 (M4V62_06045) 1275522..1277060 + 1539 WP_249586179.1 type I-E CRISPR-associated protein Cse1/CasA -
M4V62_RS06050 (M4V62_06050) 1277057..1277641 + 585 WP_249586180.1 type I-E CRISPR-associated protein Cse2/CasB -
M4V62_RS06055 (M4V62_06055) 1277638..1278984 + 1347 WP_249586181.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1273173..1287479 14306


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Helix-turn-helix domain, group 17

(84-131)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15548.92 Da        Isoelectric Point: 5.0113

>T245103 WP_249592709.1 NZ_CP097289:1273774-1274196 [Streptomyces durmitorensis]
MKADRPDLAPEVLDRTRRLMKAAVRDCLVKGHEPLIDILELPDKDDRHVLAAAIRAKAQVIVTFNLKDFPAEALAPWDVE
AVHPDAFLEAQIDLAPEIVYGEIQRIADSWKNPPGTVADVIERLDRNRLVSSAAALRALT

Download         Length: 423 bp

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16776.25 Da        Isoelectric Point: 6.2472

>AT245103 WP_249586178.1 NZ_CP097289:1273173-1273634 [Streptomyces durmitorensis]
VTKTDFRPVKLPPEKTATANRALTRVRGYLAEHPDLGQIAVKPLDDREPEPLTLPREAVELLAGLLAHLGAGRGVSIVPS
TAELTTQQAADILNVSRPFLIGLLDAGEIECRLVGTHRRITASSLMEYKQADDRRRREAADELTQLGQEMGMM

Download         Length: 462 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References