Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4179377..4180158 Replicon chromosome
Accession NZ_CP097262
Organism Salmonella enterica subsp. enterica strain B3-6

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag M3N94_RS20435 Protein ID WP_000626100.1
Coordinates 4179377..4179868 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag M3N94_RS20440 Protein ID WP_001110452.1
Coordinates 4179865..4180158 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3N94_RS20400 (4174837) 4174837..4175184 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
M3N94_RS20405 (4175160) 4175160..4176863 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
M3N94_RS20410 (4176900) 4176900..4177475 + 576 WP_001188509.1 transcriptional regulator -
M3N94_RS20420 (4177746) 4177746..4177820 - 75 Protein_3991 helix-turn-helix domain-containing protein -
M3N94_RS20425 (4178200) 4178200..4178277 + 78 Protein_3992 porin family protein -
M3N94_RS20430 (4178377) 4178377..4179129 + 753 WP_000842433.1 non-specific acid phosphatase -
M3N94_RS20435 (4179377) 4179377..4179868 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
M3N94_RS20440 (4179865) 4179865..4180158 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
M3N94_RS20445 (4180475) 4180475..4180696 + 222 WP_001576552.1 hypothetical protein -
M3N94_RS20450 (4180962) 4180962..4181837 + 876 WP_000921676.1 AraC family transcriptional regulator -
M3N94_RS20455 (4181834) 4181834..4182121 + 288 WP_001541332.1 transcriptional regulator RtsB -
M3N94_RS20460 (4182114) 4182114..4182422 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
M3N94_RS20465 (4182421) 4182421..4182669 + 249 Protein_4000 Ig-like domain-containing protein -
M3N94_RS20470 (4182781) 4182781..4182912 + 132 Protein_4001 hypothetical protein -
M3N94_RS20475 (4183206) 4183206..4184111 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T245088 WP_000626100.1 NZ_CP097262:c4179868-4179377 [Salmonella enterica subsp. enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT245088 WP_001110452.1 NZ_CP097262:c4180158-4179865 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References