Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4031356..4031906 Replicon chromosome
Accession NZ_CP097262
Organism Salmonella enterica subsp. enterica strain B3-6

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag M3N94_RS19650 Protein ID WP_001199743.1
Coordinates 4031356..4031664 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag M3N94_RS19655 Protein ID WP_001118105.1
Coordinates 4031667..4031906 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3N94_RS19630 (4027930) 4027930..4028670 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
M3N94_RS19635 (4028792) 4028792..4029322 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
M3N94_RS19640 (4029645) 4029645..4030778 + 1134 Protein_3841 IS3 family transposase -
M3N94_RS19645 (4030810) 4030810..4030950 - 141 Protein_3842 Arm DNA-binding domain-containing protein -
M3N94_RS19650 (4031356) 4031356..4031664 - 309 WP_001199743.1 CcdB family protein Toxin
M3N94_RS19655 (4031667) 4031667..4031906 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
M3N94_RS19660 (4032015) 4032015..4032263 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
M3N94_RS19665 (4032454) 4032454..4032885 - 432 Protein_3846 helix-turn-helix domain-containing protein -
M3N94_RS19675 (4033642) 4033642..4034661 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
M3N94_RS19680 (4034689) 4034689..4035219 - 531 WP_000896758.1 gluconokinase -
M3N94_RS19685 (4035436) 4035436..4036467 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4029737..4032840 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T245086 WP_001199743.1 NZ_CP097262:c4031664-4031356 [Salmonella enterica subsp. enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT245086 WP_001118105.1 NZ_CP097262:c4031906-4031667 [Salmonella enterica subsp. enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References