Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3987095..3987671 Replicon chromosome
Accession NZ_CP097262
Organism Salmonella enterica subsp. enterica strain B3-6

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag M3N94_RS19440 Protein ID WP_001131963.1
Coordinates 3987384..3987671 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag M3N94_RS19435 Protein ID WP_000063142.1
Coordinates 3987095..3987397 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3N94_RS19420 (3983605) 3983605..3985755 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
M3N94_RS19425 (3985850) 3985850..3986053 + 204 WP_000460616.1 YbdD/YjiX family protein -
M3N94_RS19430 (3986064) 3986064..3987020 + 957 WP_000187843.1 GTPase -
M3N94_RS19435 (3987095) 3987095..3987397 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
M3N94_RS19440 (3987384) 3987384..3987671 - 288 WP_001131963.1 BrnT family toxin Toxin
M3N94_RS19445 (3988088) 3988088..3989344 + 1257 Protein_3802 NERD domain-containing protein/DEAD/DEAH box helicase -
M3N94_RS19450 (3989338) 3989338..3989517 + 180 Protein_3803 DNA methyltransferase -
M3N94_RS19455 (3989507) 3989507..3990811 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T245085 WP_001131963.1 NZ_CP097262:c3987671-3987384 [Salmonella enterica subsp. enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT245085 WP_000063142.1 NZ_CP097262:c3987397-3987095 [Salmonella enterica subsp. enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References